(Q30373030)

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Directed evolution of a histone acetyltransferase--enhancing thermostability, whilst maintaining catalytic activity and substrate specificity.

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scholarly article

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Europe PubMed Central

21 June 2017

Directed evolution of a histone acetyltransferase--enhancing thermostability, whilst maintaining catalytic activity and substrate specificity. (English)

1 reference

Europe PubMed Central

21 June 2017

directed evolution

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1

object named as

Hans Leemhuis

1 reference

Europe PubMed Central

21 June 2017

Florian Hollfelder

3

object named as

Florian Hollfelder

1 reference

Europe PubMed Central

21 June 2017

author name string

Karl P Nightingale

2

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Europe PubMed Central

21 June 2017

language of work or name

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publication date

1 November 2008

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Europe PubMed Central

21 June 2017

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Europe PubMed Central

21 June 2017

275

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Europe PubMed Central

21 June 2017

5635-5647

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Europe PubMed Central

21 June 2017

22

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Europe PubMed Central

21 June 2017

Chromatin modifications and their function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

The language of covalent histone modifications

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Defining an epigenetic code

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Histone acetyltransferase complexes: one size doesn't fit all

1 reference

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21 January 2018

Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.

1 reference

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21 January 2018

Chromodomains are protein-RNA interaction modules

1 reference

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21 January 2018

Thermophilic adaptation of proteins

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21 January 2018

Physics and evolution of thermophilic adaptation

1 reference

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21 January 2018

Structural differences between mesophilic, moderately thermophilic and extremely thermophilic protein subunits: results of a comprehensive survey

1 reference

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21 January 2018

Hyperthermophilic enzymes: sources, uses, and molecular mechanisms for thermostability

1 reference

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21 January 2018

Factors enhancing protein thermostability

1 reference

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21 January 2018

Structural genomics of thermotoga maritima proteins shows that contact order is a major determinant of protein thermostability

1 reference

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21 January 2018

Entropic stabilization of proteins and its proteomic consequences

1 reference

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Design of highly stable functional GroEL minichaperones.

1 reference

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From DNA sequence to improved functionality: using protein sequence comparisons to rapidly design a thermostable consensus phytase

1 reference

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21 January 2018

Improved thermostability of bacillus circulans cyclodextrin glycosyltransferase by the introduction of a salt bridge

1 reference

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21 January 2018

Engineering an enzyme to resist boiling

1 reference

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21 January 2018

Rational engineering of enzyme stability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Directed evolution: selecting today's biocatalysts

1 reference

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21 January 2018

Milestones in directed enzyme evolution.

1 reference

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21 January 2018

Directed evolution of proteins for heterologous expression and stability.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Cumulative effect of amino acid replacements results in enhanced thermostability of potato type L alpha-glucan phosphorylase

1 reference

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21 January 2018

A thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents

1 reference

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21 January 2018

The use of forced protein evolution to investigate and improve stability of family 10 xylanases. The production of Ca2+-independent stable xylanases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Directed evolution of enzyme stability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

New genotype-phenotype linkages for directed evolution of functional proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Preparation of nucleosome core particle from recombinant histones

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A

1 reference

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21 January 2018

ASAView: database and tool for solvent accessibility representation in proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Structural determinants of the stability of thermolysin-like proteinases

1 reference

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21 January 2018

Structural and mutagenesis studies of leishmania triosephosphate isomerase: a point mutation can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power

1 reference

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21 January 2018

Strengthening the dimerisation interface of Lac repressor increases its thermostability by 40 deg. C.

1 reference

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21 January 2018

Reverse hydrophobic effects relieved by amino-acid substitutions at a protein surface.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Computational thermostabilization of an enzyme

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Energy estimation in protein design

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06689.X

21 January 2018

Advances in computational protein design

1 reference

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21 January 2018

Directed evolution of a thermostable esterase.

1 reference

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21 January 2018

Directed evolution of a thermostable phosphite dehydrogenase for NAD(P)H regeneration

1 reference

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Protein stability and surface electrostatics: a charged relationship.

1 reference

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21 January 2018

The consensus concept for thermostability engineering of proteins

1 reference

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21 January 2018

Designing thermostable proteins: ancestral mutants of 3-isopropylmalate dehydrogenase designed by using a phylogenetic tree.

1 reference

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21 January 2018

High-throughput screening for enhanced protein stability

1 reference

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21 January 2018

Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.

1 reference

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21 January 2018

Missense meanderings in sequence space: a biophysical view of protein evolution

1 reference

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The pharmaceutical potential of histone deacetylase inhibitors

1 reference

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The therapeutic uses of chromatin-modifying agents

1 reference

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Histone deacetylation in epigenetics: an attractive target for anticancer therapy

1 reference

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21 January 2018

The human histone acetyltransferase P/CAF is a promiscuous histone propionyltransferase.

1 reference

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21 January 2018

Chemical and biochemical strategies for the randomization of protein encoding DNA sequences: library construction methods for directed evolution

1 reference

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Substantial increase of protein stability by multiple disulphide bonds

1 reference

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21 January 2018

Identifiers

10.1111/J.1742-4658.2008.06689.X

1 reference

Europe PubMed Central

21 June 2017

1 reference

Europe PubMed Central

21 June 2017

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