(Q30374762)

18 August 2017

Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group. (English)

1 reference

18 August 2017

0 references

Woon Ki Lim

1

1 reference

18 August 2017

Jörg Rösgen

series ordinal

2

1 reference

18 August 2017

S Walter Englander

series ordinal

3

1 reference

18 August 2017

language of work or name

English

0 references

publication date

5 February 2009

1 reference

Proceedings of the National Academy of Sciences of the United States of America

18 August 2017

1 reference

18 August 2017

106

1 reference

18 August 2017

8

1 reference

18 August 2017

2595-2600

1 reference

Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Thermodynamic origin of hofmeister ion effects

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Anatomy of energetic changes accompanying urea-induced protein denaturation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Molecular basis of the apparent near ideality of urea solutions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Geometry of nonbonded interactions involving planar groups in proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

The interaction of guanidinium ions with a model peptide

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Preferential solvation in urea solutions at different concentrations: properties from simulation studies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

An analysis of the molecular origin of osmolyte-dependent protein stability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

A molecular mechanism for osmolyte-induced protein stability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

On the Structure of Native, Denatured, and Coagulated Proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Predicting the energetics of osmolyte-induced protein folding/unfolding.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Effect of urea on peptide conformation in water: molecular dynamics and experimental characterization

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Dissecting contributions to the denaturant sensitivities of proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Uncovering the basis for nonideal behavior of biological molecules

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Protein stability in mixed solvents: a balance of contact interaction and excluded volume

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

The molecular basis for the chemical denaturation of proteins by urea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

The hydration structure of guanidinium and thiocyanate ions: implications for protein stability in aqueous solution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

pH corrections and protein ionization in water/guanidinium chloride.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Molecular dynamics simulations of the unfolding of barnase in water and 8 M aqueous urea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

The control of protein stability and association by weak interactions with water: how do solvents affect these processes?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Primary structure effects on peptide group hydrogen exchange

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Urea unfolding of peptide helices as a model for interpreting protein unfolding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Living with water stress: evolution of osmolyte systems

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Nuclear magnetic resonance study of the exchange rates of the peptide protons of glycylglycine and triglycine in water and aqueous urea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

20 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

20 June 2018

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

The crystal and molecular structure of a complex formed by guanidine hydrochloride and glycylglycine, (C(NH2)3)CI C4N2O3H8.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Urea and guanidine hydrochloride denaturation of ribonuclease, lysozyme, alpha-chymotrypsin, and beta-lactoglobulin.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

Amino-aromatic interactions in proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650309

The dominant interaction between peptide and urea is electrostatic in nature: a molecular dynamics simulation study

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Interactions between hydrophobic and ionic solutes in aqueous guanidinium chloride and urea solutions: lessons for protein denaturation mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Interaction of urea with amino acids: implications for urea-induced protein denaturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

The thermodynamics of solvent exchange.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Extension of the theory of linked functions to incorporate the effects of protein hydration

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Quantifying the roles of water and solutes (denaturants, osmolytes, and Hofmeister salts) in protein and model processes using the solute partitioning model

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Structural thermodynamics of protein preferential solvation: osmolyte solvation of proteins, aminoacids, and peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

The nature and transport mechanism of hydrated hydroxide ions in aqueous solution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

The nature of the hydrated excess proton in water

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

The structure of aqueous guanidinium chloride solutions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Impact of urea on water structure: a clue to its properties as a denaturant?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Additive transfer free energies of the peptide backbone unit that are independent of the model compound and the choice of concentration scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Denaturation of Proteins by Urea and Related Substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0812588106

Limited validity of group additivity for the folding energetics of the peptide group

21 January 2018

1 reference

12 December 2020

THE EFFECT OF COMPOUNDS OF THE UREA-GUANIDINIUM CLASS ON THE ACTIVITY COEFFICIENT OF ACETYLTETRAGLYCINE ETHYL ESTER AND RELATED COMPOUNDS

1 reference

12 December 2020

Viscosity and density of aqueous solutions of urea and guanidine hydrochloride

1 reference

12 December 2020

Acid-base titrations in concentrated guanidine hydrochloride. Dissociation constants of the guamidinium ion and of some amino acids

1 reference

12 December 2020

Aqueous urea solutions: structure, energetics, and urea aggregation

1 reference

12 December 2020

Planar stacking interactions of arginine and aromatic side-chains in proteins

1 reference

12 December 2020

Protein interactions with urea and guanidinium chloride. A calorimetric study

1 reference

12 December 2020

Thermodynamic analysis of interactions between denaturants and protein surface exposed on unfolding: interpretation of urea and guanidinium chloride m-values and their correlation with changes in accessible surface area (ASA) using preferential inte

1 reference

12 December 2020

Forcing thermodynamically unfolded proteins to fold

1 reference

12 December 2020

Structural details of urea binding to barnase: a molecular dynamics analysis

1 reference

12 December 2020

Guanidine hydrochloride unfolding of peptide helices: separation of denaturant and salt effects

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0812588106

1 reference

18 August 2017

0 references

1 reference

18 August 2017

PubMed publication ID

19196963

1 reference