(Q30391389)

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Effects of the nicotinic α7 receptor partial agonist GTS-21 on NMDA-glutamatergic receptor related deficits in sensorimotor gating and recognition memory in rats

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scholarly article

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Europe PubMed Central

15 August 2017

Effects of the nicotinic α7 receptor partial agonist GTS-21 on NMDA-glutamatergic receptor related deficits in sensorimotor gating and recognition memory in rats (English)

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Europe PubMed Central

15 August 2017

2

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8 June 2020

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Patrick M Callahan

1

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8 June 2020

Ashok Tehim

3

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8 June 2020

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5 March 2014

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15 August 2017

Psychopharmacology

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8 June 2020

231

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8 June 2020

18

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8 June 2020

3695-3706

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8 June 2020

https://scigraph.springernature.com/pub.10.1007/s00213-014-3509-2

0 references

NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia

1 reference

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1 reference

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20 June 2018

A randomized exploratory trial of an α-7 nicotinic receptor agonist (TC-5619) for cognitive enhancement in schizophrenia

1 reference

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20 June 2018

Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia

1 reference

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Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates

1 reference

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20 June 2018

Short-term tropisetron treatment and cognitive and P50 auditory gating deficits in schizophrenia

1 reference

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20 June 2018

Nicotinic acetylcholine receptors: from basic science to therapeutics

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20 June 2018

EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

1 reference

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20 June 2018

Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models.

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20 June 2018

Glutamate and nicotinic receptor interactions in working memory: importance for the cognitive impairment of schizophrenia

1 reference

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20 June 2018

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

1 reference

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20 June 2018

RG3487, a novel nicotinic α7 receptor partial agonist, improves cognition and sensorimotor gating in rodents.

1 reference

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20 June 2018

Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism

1 reference

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20 June 2018

A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia

1 reference

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20 June 2018

Correlation of prepulse inhibition and Wisconsin Card Sorting Test in schizophrenia and controls: effects of smoking status

1 reference

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20 June 2018

A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists.

1 reference

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20 June 2018

TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

1 reference

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20 June 2018

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

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20 June 2018

Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders

1 reference

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20 June 2018

Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)

1 reference

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20 June 2018

The cognitive neuroscience of memory function and dysfunction in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Initial phase 2 trial of a nicotinic agonist in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Oral haloperidol or risperidone treatment in rats: temporal effects on nerve growth factor receptors, cholinergic neurons, and memory performance

1 reference

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20 June 2018

Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response

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20 June 2018

Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Distinct roles for medial temporal lobe structures in memory for objects and their locations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.

1 reference

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20 June 2018

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

1 reference

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20 June 2018

Time-dependent effects of haloperidol and ziprasidone on nerve growth factor, cholinergic neurons, and spatial learning in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Tropisetron improves deficits in auditory P50 suppression in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

A systematic review of the prevalence of schizophrenia

1 reference

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20 June 2018

The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetize

1 reference

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The medial temporal lobe

1 reference

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20 June 2018

Preattentional and attentional cognitive deficits as targets for treating schizophrenia

1 reference

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20 June 2018

Half a century of antipsychotics and still a central role for dopamine D2 receptors

1 reference

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20 June 2018

Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Influence of cigarette smoking on prepulse inhibition of the acoustic startle response in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Effects of ketamine in normal and schizophrenic volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges

1 reference

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20 June 2018

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

1 reference

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20 June 2018

Blockade of drug-induced deficits in prepulse inhibition of acoustic startle by ziprasidone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Impaired recognition memory in rats after damage to the hippocampus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

NMDA receptor hypofunction model of schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Nicotinic modulation of glutamate and GABA synaptic transmission of hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Schizophrenia, sensory gating, and nicotinic receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Glutamate in schizophrenia: clinical and research implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Startle habituation and sensorimotor gating in schizophrenia and related animal models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

20 June 2018

The role of the hippocampus in object recognition in rats: examination of the influence of task parameters and lesion size

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

A preliminary study of the effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanisms.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN3462

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Translating the basic and clinical cognitive neuroscience of schizophrenia to drug development and clinical trials of antipsychotic medications

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: role of alpha 7 nicotinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron: role of alpha7 nicotinic receptors.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Ameliorating effects of tropisetron on dopaminergic disruption of prepulse inhibition via the alpha(7) nicotinic acetylcholine receptor in Wistar rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: implications for therapy of cognitive dysfunction in schizophrenia.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Effects of the novel α7 nicotinic acetylcholine receptor agonist ABT-107 on sensory gating in DBA/2 mice: pharmacodynamic characterization.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhanceme

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Puzzling over schizophrenia: schizophrenia as a pathway disease

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

1 reference

https://api.crossref.org/works/10.1007%2FS00213-014-3509-2

21 January 2018

Sex-dependent hippocampal volume reductions in schizophrenia relate to episodic memory deficits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

26 November 2018

Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

26 November 2018

Memory impairment in schizophrenia: a meta-analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

26 November 2018

Impaired recognition memory in patients with lesions limited to the hippocampal formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748388

26 November 2018

Identifiers

10.1007/S00213-014-3509-2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595504%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

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1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595504%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24595504%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

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