(Q30412009)

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Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration

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25 February 2020

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration (English)

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25 February 2020

Alzheimer's disease

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pathophysiology

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frontotemporal lobar degeneration

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Grazyna Niewiadomska

17

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25 February 2020

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V Melis

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25 February 2020

C Zabke

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25 February 2020

K Stamer

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25 February 2020

M Magbagbeolu

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K Schwab

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P Marschall

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25 February 2020

R W Veh

7

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S Bachmann

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S Deiana

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P-H Moreau

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K Davidson

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K A Harrington

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J E Rickard

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D Horsley

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R Garman

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25 February 2020

M Mazurkiewicz

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C M Wischik

18

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C R Harrington

19

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25 February 2020

G Riedel

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F Theuring

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25 February 2020

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19 December 2014

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25 February 2020

Cellular and Molecular Life Sciences

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25 February 2020

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25 February 2020

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25 February 2020

2199-2222

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25 February 2020

copyright license

Creative Commons Attribution 4.0 International

19 December 2014

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Europe PubMed Central

11 June 2022

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based on heuristic

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https://scigraph.springernature.com/pub.10.1007/s00018-014-1804-z

0 references

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

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Distinct tau prion strains propagate in cells and mice and define different tauopathies

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Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

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Truncation of tau at E391 promotes early pathologic changes in transgenic mice

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Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy

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Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury

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A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model

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Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?

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Transmission and spreading of tauopathy in transgenic mouse brain

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Propagation of tau misfolding from the outside to the inside of a cell.

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Memory loss in Alzheimer's disease: implications for development of therapeutics

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Competition between the signal sequence and a 3'UTR localisation signal during redirection of beta-globin mRNA to the endoplasmic reticulum: implications for biotechnology.

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20 June 2018

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

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20 June 2018

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

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20 June 2018

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

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20 June 2018

Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory

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20 June 2018

Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections.

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A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

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Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease

1 reference

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20 June 2018

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

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20 June 2018

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

1 reference

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20 June 2018

Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria

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Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

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20 June 2018

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

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The distribution of tau in the mammalian central nervous system

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20 June 2018

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

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20 June 2018

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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20 June 2018

A progressive deposition of paired helical filaments (PHF) in the brain characterizes the evolution of dementia in Alzheimer's disease. An immunocytochemical study with a monoclonal antibody against the PHF core.

1 reference

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20 June 2018

Tissue-specific control elements of the Thy-1 gene

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20 June 2018

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1 reference

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20 June 2018

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20 June 2018

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51

1 reference

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20 June 2018

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1 reference

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20 June 2018

Spatial memory and hippocampal function

1 reference

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20 June 2018

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

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21 January 2018

Examination of phosphorylated tau protein as a PHF-precursor at early stage Alzheimer's disease.

1 reference

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21 January 2018

Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients.

1 reference

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21 January 2018

Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal Study on Dementia.

1 reference

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21 January 2018

Modeling the relation between neurofibrillary tangles and intellectual status.

1 reference

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21 January 2018

Memory and mental status correlates of modified Braak staging.

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21 January 2018

Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes.

1 reference

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21 January 2018

Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.

1 reference

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21 January 2018

Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease.

1 reference

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21 January 2018

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

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21 January 2018

Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration.

1 reference

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21 January 2018

Truncated tau expression levels determine life span of a rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load.

1 reference

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21 January 2018

Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats.

1 reference

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21 January 2018

Age-dependent changes in hippocampal synaptic transmission and plasticity in the PLB1Triple Alzheimer mouse.

1 reference

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21 January 2018

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

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21 January 2018

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68.

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21 January 2018

Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.

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21 January 2018

Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease.

1 reference

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21 January 2018

Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease

1 reference

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21 January 2018

Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice.

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21 January 2018

Dissociation of cholinergic function in spatial and procedural learning in rats.

1 reference

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21 January 2018

Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.

1 reference

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21 January 2018

Delay-dependent impairment of a matching-to-place task with chronic and intrahippocampal infusion of the NMDA-antagonist D-AP5.

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21 January 2018

Early behavioural markers of disease in P301S tau transgenic mice

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21 January 2018

Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain.

1 reference

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21 January 2018

Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau.

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21 January 2018

Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy.

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21 January 2018

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

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26 November 2018

Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.

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26 November 2018

Fibrillogenic nuclei composed of P301L mutant tau induce elongation of P301L tau but not wild-type tau

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12 December 2020

based on heuristic

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Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/25523019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00018-014-1804-Z

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25523019%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25523019%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25523019%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

ResearchGate publication ID

0 references

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