(Q30424913)

10 August 2017

Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes (English)

1 reference

10 August 2017

1

Chris R Feldman

0 references

Michael E. Pfrender

series ordinal

4

object named as

Michael E Pfrender

1 reference

10 August 2017

Edmund D Brodie

2

1 reference

PMCID

3311348

10 August 2017

Edmund D Brodie

series ordinal

3

1 reference

PMCID

3311348

10 August 2017

language of work or name

English

0 references

publication date

5 March 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

10 August 2017

1 reference

10 August 2017

109

1 reference

10 August 2017

4556-4561

1 reference

10 August 2017

12

1 reference

Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

The phylogeny of advanced snakes (Colubroidea), with discovery of a new subfamily and comparison of support methods for likelihood trees

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Genetic architecture of a feeding adaptation: garter snake (Thamnophis) resistance to tetrodotoxin bearing prey

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

The chemical and evolutionary ecology of tetrodotoxin (TTX) toxicity in terrestrial vertebrates

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

The tetrodotoxin binding site is within the outer vestibule of the sodium channel

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Functional expression of an arachnid sodium channel reveals residues responsible for tetrodotoxin resistance in invertebrate sodium channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

The evolutionary origins of beneficial alleles during the repeated adaptation of garter snakes to deadly prey

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

The causes of repeated genetic evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Is genetic evolution predictable?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Phenotypic mismatches reveal escape from arms-race coevolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Two critical residues in p-loop regions of puffer fish Na+ channels on TTX sensitivity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Direct demonstration of an adaptive constraint

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Evo-devo and constraints on selection

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Darwinian evolution can follow only very few mutational paths to fitter proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Genetic basis of tetrodotoxin resistance in pufferfishes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Missense meanderings in sequence space: a biophysical view of protein evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Marine toxins and nonmarine toxins: convergence or symbiotic organisms?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Parallel evolution and inheritance of quantitative traits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

UCSF Chimera--a visualization system for exploratory research and analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

The evolutionary response of predators to dangerous prey: hotspots and coldspots in the geographic mosaic of coevolution between garter snakes and newts.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Mechanisms of Adaptation in a Predator-Prey Arms Race: TTX-Resistant Sodium Channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

The adaptive landscape as a conceptual bridge between micro- and macroevolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Molecular architecture of the voltage-dependent Na channel: functional evidence for alpha helices in the pore

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

First occurrence of tetrodotoxin in a dendrobatid frog (Colostethus inguinalis), with further reports for the bufonid genus Atelopus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Pumiliotoxin B binds to a site on the voltage-dependent sodium channel that is allosterically coupled to other binding sites

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Distribution of tetrodotoxin, 6-epitetrodotoxin, and 11-deoxytetrodotoxin in newts.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Molecular localization of an ion-binding site within the pore of mammalian sodium channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Tetrodotoxin: Occurrence in Atelopid Frogs of Costa Rica

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Causes and evolutionary significance of genetic convergence.

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Investigations on the Skin Toxin of the Adult Rough-Skinned Newt, Taricha granulosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Parallel arms races between garter snakes and newts involving tetrodotoxin as the phenotypic interface of coevolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Occurrence of tetrodotoxin in the skin of a rhacophoridid frog Polypedates sp. from Bangladesh.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Constraints on phenotypic evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Branch lengths, support, and congruence: testing the phylogenomic approach with 20 nuclear loci in snakes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Resistance of neonates and field-collected garter snakes (Thamnophis spp.) to tetrodotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

A tryptophan residue (W736) in the amino-terminus of the P-segment of domain II is involved in pore formation in Na(v)1.4 voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1113468109

Population genetics, pleiotropy, and the preferential fixation of mutations during adaptive evolution.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

Site-directed mutagenesis of the putative pore region of the rat IIA sodium channel.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311348

KcsA crystal structure as framework for a molecular model of the Na(+) channel pore

26 November 2018

1 reference

12 December 2020

Interaction of pumiliotoxin B with an "alkaloid-binding domain" on the voltage-dependent sodium channel

1 reference

12 December 2020

FISHER'S MODEL AND THE GENOMICS OF ADAPTATION: RESTRICTED PLEIOTROPY, HETEROGENOUS MUTATION, AND PARALLEL EVOLUTION

1 reference

12 December 2020

EVOLUTIONARY RESPONSE OF PREDATORS TO DANGEROUS PREY: PREADAPTATION AND THE EVOLUTION OF TETRODOTOXIN RESISTANCE IN GARTER SNAKES.

1 reference

12 December 2020

ADAPTIVE RADIATION ALONG GENETIC LINES OF LEAST RESISTANCE.

1 reference

12 December 2020

TETRODOTOXIN RESISTANCE IN GARTER SNAKES: AN EVOLUTIONARY RESPONSE OF PREDATORS TO DANGEROUS PREY.

1 reference

12 December 2020

Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis

1 reference

12 December 2020

Cysteine mapping in the ion selectivity and toxin binding region of the cardiac Na+ channel pore

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1113468109

1 reference

10 August 2017

0 references

1 reference

10 August 2017

1 reference

PMCID

3311348