(Q30426842)

11 August 2017

Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting (English)

1 reference

11 August 2017

1 reference

4

David G Kirsch

1 reference

11 August 2017

Brian Belyea

1

1 reference

11 August 2017

Julie Grondin Kephart

series ordinal

2

1 reference

11 August 2017

Jordan Blum

series ordinal

3

1 reference

11 August 2017

Corinne M Linardic

series ordinal

5

1 reference

11 August 2017

30 April 2012

1 reference

11 August 2017

1 reference

11 August 2017

2012

1 reference

11 August 2017

406239

1 reference

Creative Commons Attribution 3.0 Unported

11 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway

20 June 2018

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Origin of vertebrate limb muscle: the role of progenitor and myoblast populations

20 June 2018

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Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.

20 June 2018

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CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres

20 June 2018

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Mechanisms and functions of Hedgehog signalling across the metazoa

20 June 2018

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Winning WNT: race to Wnt signaling inhibitors

20 June 2018

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An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

20 June 2018

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A preclinical and clinical study of lithium in low-grade neuroendocrine tumors

20 June 2018

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Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma

20 June 2018

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Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

20 June 2018

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Myogenesis and rhabdomyosarcoma the Jekyll and Hyde of skeletal muscle

20 June 2018

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Psychopharmacology of pediatric bipolar disorders in children and adolescents

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

20 June 2018

1 reference

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Impaired Wnt signaling in embryonal rhabdomyosarcoma cells from p53/c-fos double mutant mice

20 June 2018

1 reference

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Childhood rhabdomyosarcoma: new insight on biology and treatment

20 June 2018

1 reference

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Role of secreted frizzled-related protein 3 in human renal cell carcinoma

20 June 2018

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Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells

20 June 2018

1 reference

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The Notch effector Hey1 associates with myogenic target genes to repress myogenesis.

20 June 2018

1 reference

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Direct inhibition of the NOTCH transcription factor complex

20 June 2018

1 reference

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Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties

20 June 2018

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Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803.

20 June 2018

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

20 June 2018

1 reference

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Wnt/beta-catenin signaling: components, mechanisms, and diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Novel small molecule activators of beta-catenin-mediated signaling pathway: structure-activity relationships of indirubins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Notch inhibitors as a new tool in the war on cancer: a pathway to watch

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

The genetics of vertebrate myogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Perinatal depression: treatment options and dilemmas.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

PAX3-FOXO1 fusion gene in rhabdomyosarcoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Inhibition of myoblast differentiation by Sfrp1 and Sfrp2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Cellular heterogeneity during vertebrate skeletal muscle development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Mining the Wnt pathway for cancer therapeutics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Wnt/beta-catenin signaling in development and disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: the Children's Oncology Group

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Shh controls epithelial proliferation via independent pathways that converge on N-Myc

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Embryonic myogenesis pathways in muscle regeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Looking back to the embryo: defining transcriptional networks in adult myogenesis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Small molecule modulation of Smoothened activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Analysis of the PTCH coding region in human rhabdomyosarcoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Patched acts catalytically to suppress the activity of Smoothened

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Sonic hedgehog is a survival factor for hypaxial muscles during mouse development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Nevoid basal cell carcinoma (Gorlin) syndrome: unanswered issues

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

A molecular mechanism for the effect of lithium on development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Autoproteolysis in hedgehog protein biogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

APC mutations occur early during colorectal tumorigenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV.

20 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Survival after relapse in children and adolescents with rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Expression of beta-catenin is necessary for physiological growth of adult skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Pleiotropic effects of sonic hedgehog on muscle satellite cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Sonic hedgehog inhibits the terminal differentiation of limb myoblasts committed to the slow muscle lineage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Beta-catenin mutation does not seem to have an effect on the tumorigenesis of pediatric rhabdomyosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

beta-Catenin promotes self-renewal of skeletal-muscle satellite cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F406239

Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350847

Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2

26 November 2018

1 reference

12 December 2020

Nuclear beta-catenin in mesenchymal tumors

1 reference

12 December 2020

Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy

1 reference

12 December 2020

Beta catenin-independent activation of MyoD in presomitic mesoderm requires PKC and depends on Pax3 transcriptional activity

1 reference

12 December 2020

European intergroup studies (MMT4-89 and MMT4-91) on childhood metastatic rhabdomyosarcoma: final results and analysis of prognostic factors

1 reference

12 December 2020

Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study

1 reference

12 December 2020

Muscling in: Uncovering the origins of rhabdomyosarcoma

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/406239

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22619564

1 reference