(Q30437051)

21 June 2017

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title

PKC eta as a therapeutic target in glioblastoma multiforme (English)

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21 June 2017

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Patrick M Martin

1

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21 June 2017

Isa M Hussaini

series ordinal

2

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21 June 2017

language of work or name

English

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publication date

1 April 2005

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Expert Opinion on Therapeutic Targets

21 June 2017

published in

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21 June 2017

volume

9

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21 June 2017

issue

2

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21 June 2017

page(s)

299-313

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Gliomagenesis: genetic alterations and mouse models

21 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Molecular analysis of glioblastoma: pathway profiling and its implications for patient therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Malignant glioma: genetics and biology of a grave matter.

21 January 2018

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Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Phorbol 12-myristate 13-acetate induces protein kinase ceta-specific proliferative response in astrocytic tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Diacylglycerol kinase in the central nervous system--molecular heterogeneity and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Regulation of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C: a target for anticancer drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Increased protein kinase C delta in mammary tumor cells: relationship to transformtion and metastatic progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Altered expression and localization of PKC eta in human breast tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C isoform ? overexpression in C6 glioma cells and its role in cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Restoration of growth arrest by p16INK4, p21WAF1, pRB, and p53 is dependent on the integrity of the endogenous cell-cycle control pathways in human glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

IFNgamma inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Opposite effects of the overexpression of protein kinase C gamma and delta on the growth properties of human glioma cell line U251 MG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Differential role of specific PKC isoforms in the proliferation of glial cells and the expression of the astrocytic markers GFAP and glutamine synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Akt is activated in response to an apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

A protective role of PKCepsilon against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

The role of matrix metalloproteinase genes in glioma invasion: co-dependent and interactive proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

The role of protein kinase Calpha in U-87 glioma invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

PKC controls HGF-dependent c-Met traffic, signalling and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

PKC epsilon controls the traffic of beta1 integrins in motile cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Enhancement of migration by protein kinase Calpha and inhibition of proliferation and cell cycle progression by protein kinase Cdelta in capillary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C inhibitors as novel anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Differential responses of human neuroblastoma and glioblastoma to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Tamoxifen-resistant glioma-cell sub-populations are characterized by increased migration and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Bryostatin-1: a novel PKC inhibitor in clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

A phase II trial of bryostatin-1 in patients with metastatic or recurrent squamous cell carcinoma of the head and neck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Sensitivity of human glioma U-373MG cells to radiation and the protein kinase C inhibitor, calphostin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Calphostin C-mediated translocation and integration of Bax into mitochondria induces cytochrome c release before mitochondrial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Down-regulation of protein kinase Ceta by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

siRNA agents inhibit oncogene expression and attenuate human tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Subtype- and species-specific knockdown of PKC using short interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

The role of protein kinase C in cell surface signal transduction and tumour promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.299

UCN-1028A, a novel and specific inhibitor of protein kinase C, from Cladosporium

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.153

Identifiers

DOI

10.1517/14728222.9.2.299

1 reference

21 June 2017

1 reference