(Q30437514)

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Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

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scholarly article

1 reference

Europe PubMed Central

19 August 2017

Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes (English)

1 reference

Europe PubMed Central

19 August 2017

transmembrane protein

0 references

Vsevolod Katritch

1

1 reference

Europe PubMed Central

19 August 2017

7

object named as

Ruben Abagyan

0 references

3

object named as

Vadim Cherezov

1 reference

Europe PubMed Central

19 August 2017

Michael A Hanson

4

object named as

Michael A Hanson

1 reference

Europe PubMed Central

19 August 2017

author name string

Kimberly A Reynolds

2

1 reference

Europe PubMed Central

19 August 2017

Christopher B Roth

5

1 reference

Europe PubMed Central

19 August 2017

Mark Yeager

6

1 reference

Europe PubMed Central

19 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 July 2009

1 reference

Europe PubMed Central

19 August 2017

Journal of Molecular Recognition

1 reference

Europe PubMed Central

19 August 2017

22

1 reference

Europe PubMed Central

19 August 2017

4

1 reference

Europe PubMed Central

19 August 2017

307-318

1 reference

Europe PubMed Central

19 August 2017

Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Structure of a beta1-adrenergic G-protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

1 reference

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20 June 2018

Structural diversity of G protein-coupled receptors and significance for drug discovery

1 reference

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20 June 2018

New G-protein-coupled receptor crystal structures: insights and limitations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Conformational complexity of G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

3-Dimensional structures of G protein-coupled receptors and binding sites of agonists and antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Role of group-conserved residues in the helical core of beta2-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

G protein coupled receptor structure and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

GPCR agonists and antagonists in the clinic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Molecular mechanism of 7TM receptor activation--a global toggle switch model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Serine and threonine residues bend alpha-helices in the chi(1) = g(-) conformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Effect of multiple serine/alanine mutations in the transmembrane spanning region V of the D2 dopamine receptor on ligand binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Ser203 as well as Ser204 and Ser207 in fifth transmembrane domain of the human beta2-adrenoceptor contributes to agonist binding and receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Differential contribution of two serine residues of wild type and constitutively active beta2-adrenoceptors to the interaction with beta2-selective agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand-binding specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

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Characterization of [3H](+/-)carazolol binding to beta-adrenergic receptors. Application to study of beta-adrenergic receptor subtypes in canine ventricular myocardium and lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

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Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

Site-directed mutagenesis of the human dopamine D2 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693451

20 June 2018

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

21 January 2018

Selective structure-based virtual screening for full and partial agonists of the beta2 adrenergic receptor

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

21 January 2018

"Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor.

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

21 January 2018

Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

21 January 2018

Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

21 January 2018

Residues in the fifth membrane-spanning segment of the dopamine D2 receptor exposed in the binding-site crevice.

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

21 January 2018

Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

21 January 2018

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

21 January 2018

Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines

1 reference

https://api.crossref.org/works/10.1002%2FJMR.949

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Deterministic features of side-chain main-chain hydrogen bonds in globular protein structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/19353579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states

1 reference

https://pubmed.ncbi.nlm.nih.gov/19353579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19353579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19353579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unique nature of the serine interactions for alpha 1-adrenergic receptor agonist binding and activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19353579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the seventh transmembrane region in high affinity binding of a beta 2-selective agonist TA-2005

1 reference

https://pubmed.ncbi.nlm.nih.gov/19353579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/JMR.949

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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