(Q30442799)

21 August 2017

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments (English)

1 reference

21 August 2017

14

Peter Nygren

1 reference

21 August 2017

15

Rolf Larsson

1 reference

21 August 2017

16

Stig Linder

1 reference

21 August 2017

10

Leoni A Kunz Schughart

1 reference

21 August 2017

2

Mårten Fryknäs

1 reference

21 August 2017

11

Linda Rickardson

1 reference

21 August 2017

13

Joachim Gullbo

1 reference

21 August 2017

6

Maria Hägg Olofsson

1 reference

21 August 2017

Xiaonan Zhang

1

1 reference

21 August 2017

Emma Hernlund

3

1 reference

21 August 2017

Walid Fayad

4

1 reference

21 August 2017

Angelo De Milito

5

1 reference

21 August 2017

Vladimir Gogvadze

7

1 reference

21 August 2017

Long Dang

8

1 reference

21 August 2017

Sven Påhlman

9

1 reference

21 August 2017

Padraig D'Arcy

12

1 reference

21 August 2017

language of work or name

English

0 references

publication date

1 January 2014

1 reference

21 August 2017

Nature Communications

1 reference

21 August 2017

5

1 reference

21 August 2017

3295

1 reference

Creative Commons Attribution 3.0 Unported

21 August 2017

start time

18 February 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Increased oxidative metabolism in the Li-Fraumeni syndrome

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Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.

20 June 2018

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Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

20 June 2018

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20 June 2018

Mitochondria and cancer

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Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death

20 June 2018

1 reference

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Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties

20 June 2018

1 reference

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Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

20 June 2018

1 reference

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Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

20 June 2018

1 reference

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Multicellular tumor spheroids: an underestimated tool is catching up again.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Principles of cancer therapy: oncogene and non-oncogene addiction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Effect of HIF-1 modulation on the response of two- and three-dimensional cultures of human colon cancer cells to 5-fluorouracil

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

AMP-activated protein kinase and human cancer: cancer metabolism revisited

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

The fluorometric microculture cytotoxicity assay

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Resistance to chemotherapy in cancer: a complex and integrated cellular response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

A reliable tool to determine cell viability in complex 3-d culture: the acid phosphatase assay

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

The third dimension bridges the gap between cell culture and live tissue

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

TOR signaling in growth and metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Early mitochondrial alterations in ATRA-induced cell death

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Repopulation of cancer cells during therapy: an important cause of treatment failure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Metformin and reduced risk of cancer in diabetic patients

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Autophagy in health and disease: a double-edged sword

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Exploiting tumour hypoxia in cancer treatment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

A novel high-through-put assay for screening of pro-apoptotic drugs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Hypoxia--a key regulatory factor in tumour growth

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Tumor physiology and drug resistance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

In vivo control of respiration by cytochrome c oxidase in human cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Metabolic imaging in multicellular spheroids of oncogene-transfected fibroblasts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Acquired multicellular-mediated resistance to alkylating agents in cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

The glucose distribution in 9L rat brain multicell tumor spheroids and its effect on cell necrosis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Comparative pO2 measurements in cell spheroids cultured with different techniques

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

20 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4295

Incorporating energy metabolism into a growth model of multicellular tumor spheroids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4295

Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4295

Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4295

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4295

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4295

Metabolite composition in breast tumors examined by proton nuclear magnetic resonance spectroscopy.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929804

Hypoxia inhibits G1/S transition through regulation of p27 expression

26 November 2018

1 reference

12 December 2020

Selective toxicity of rhodamine 123 in carcinoma cells in vitro

1 reference

12 December 2020

Interaction of rhodamine 123 with mitochondria isolated from drug-sensitive and -resistant Friend leukemia cells

1 reference

12 December 2020

Tumor Proliferative Fraction in Solid Malignant Neoplasms A Comparative Study of Ki-67 Immunostaining and Flow Cytometric Determinations

1 reference

12 December 2020

Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization

1 reference

12 December 2020

Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS4295

1 reference

Dimensions Publication ID

21 August 2017

0 references

1012712523

0 references

Fatcat ID

release_d6eiy4wg6nghzgwxg7qgffvgku

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d6eiy4wg6nghzgwxg7qgffvgku

24 November 2022

mapped directly with Wikidata item

1 reference

21 August 2017

1 reference