(Q37079652)

18 August 2017

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title

Resistance to chemotherapy in cancer: a complex and integrated cellular response (English)

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18 August 2017

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Howard R Mellor

1

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18 August 2017

Richard Callaghan

series ordinal

2

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18 August 2017

publication date

7 February 2008

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18 August 2017

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18 August 2017

volume

81

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18 August 2017

issue

4

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18 August 2017

page(s)

275-300

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The complexity of p53 modulation: emerging patterns from divergent signals

18 August 2017

cites work

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Apoptosis - the p53 network

21 January 2018

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Regulation and activation of p53 and its family members

21 January 2018

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Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer

21 January 2018

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p53 and chemosensitivity.

21 January 2018

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The cellular response to general and programmed DNA double strand breaks

21 January 2018

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The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

21 January 2018

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The multifaceted mismatch-repair system

21 January 2018

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DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents.

21 January 2018

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The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death

21 January 2018

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Apoptosis effector mechanisms: a requiem performed in different keys

21 January 2018

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Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability

21 January 2018

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The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes

21 January 2018

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Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

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Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death

21 January 2018

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DNA methylation as a therapeutic target in cancer

21 January 2018

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Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

21 January 2018

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Epigenetic silencing of the MGMT gene in cancer.

21 January 2018

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Topoisomerase enzymes as therapeutic targets for cancer chemotherapy

21 January 2018

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Topoisomerase I inhibitors: camptothecins and beyond

21 January 2018

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Etoposide, topoisomerase II and cancer

21 January 2018

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Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan

21 January 2018

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On the Origin of Cancer Cells

21 January 2018

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21 January 2018

Are cancer cells acidic?

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Studies of human tumors by MRS: a review

21 January 2018

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The relevance of tumour pH to the treatment of malignant disease

21 January 2018

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Weak acids, weak bases, and intracellular pH

21 January 2018

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Enhancement of chemotherapy by manipulation of tumour pH.

21 January 2018

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DNA flow cytometry in surgically treated lung cancer--prognostic significance

21 January 2018

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p27 as a target for cancer therapeutics

21 January 2018

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Ki-67 labeling index is a more reliable measure of solid tumor proliferative activity than tritiated thymidine labeling

21 January 2018

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The Ki-67 protein: from the known and the unknown

21 January 2018

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A model of quiescent tumour microregions for evaluating multicellular resistance to chemotherapeutic drugs.

21 January 2018

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Oncogenic alterations of metabolism

21 January 2018

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Hypoxia--a key regulatory factor in tumour growth

21 January 2018

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

21 January 2018

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Expression of hypoxia-inducible factor 1: mechanisms and consequences

21 January 2018

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Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies.

21 January 2018

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Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia

21 January 2018

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Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species

21 January 2018

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Chemoresistance in solid tumours

21 January 2018

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Intratumour heterogeneity in the uptake of macromolecular therapeutic agents in human melanoma xenografts

21 January 2018

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Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function

21 January 2018

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High interstitial fluid pressure - an obstacle in cancer therapy

21 January 2018

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Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumour model.

21 January 2018

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

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Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

21 January 2018

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Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines

21 January 2018

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Basis for design and development of platinum(IV) anticancer complexes

21 January 2018

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Glutathione induces cellular resistance against cationic dinuclear platinum anticancer drugs

21 January 2018

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Kinetic study on the reaction of cisplatin with metallothionein

21 January 2018

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Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients.

21 January 2018

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Nuclear metallothionein expression correlates with cisplatin resistance of ovarian cancer cells and poor clinical outcome.

21 January 2018

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Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma

21 January 2018

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Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers

21 January 2018

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Expression of cytochrome P450 in lung tumor

21 January 2018

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Prediction of response to docetaxel by immunohistochemical analysis of CYP3A4 expression in human breast cancers

21 January 2018

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DNA repair: enzymatic mechanisms and relevance to drug response

21 January 2018

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DNA and its associated processes as targets for cancer therapy

21 January 2018

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Alkylation damage in DNA and RNA--repair mechanisms and medical significance

21 January 2018

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DNA glycosylases in the base excision repair of DNA

21 January 2018

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Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes

21 January 2018

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Immunohistological examination of the inter- and intracellular distribution of O6-alkylguanine DNA-alkyltransferase in human liver and melanoma

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

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CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas

21 January 2018

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Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

21 January 2018

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

21 January 2018

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Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

21 January 2018

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A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma

21 January 2018

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Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model

21 January 2018

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Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors

21 January 2018

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Insights into oxazaphosphorine resistance and possible approaches to its circumvention.

21 January 2018

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Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics

21 January 2018

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ABCC2-mediated biliary transport of 4-glutathionylcyclophosphamide and its contribution to elimination of 4-hydroxycyclophosphamide in rat.

21 January 2018

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Human multidrug resistance associated protein 4 confers resistance to camptothecins.

21 January 2018

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Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: the Austrian Breast and Colorectal Cancer Study Group

21 January 2018

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The response to cyclophosphamide in steroid-sensitive nephrotic syndrome is influenced by polymorphic expression of glutathion-S-transferases-M1 and -P1.

21 January 2018

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Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemo

21 January 2018

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Phenolic antioxidant-induced overexpression of class-3 aldehyde dehydrogenase and oxazaphosphorine-specific resistance.

21 January 2018

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Structure, Recognition, and Processing of Cisplatin-DNA Adducts.

21 January 2018

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ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients

21 January 2018

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Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy

21 January 2018

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Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1

21 January 2018

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Multivariate analysis for prognostic significance of histologic subtype, GST-pi, MDR-1, and p53 in stages II-IV ovarian cancer.

21 January 2018

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The copper export pump ATP7B modulates the cellular pharmacology of carboplatin in ovarian carcinoma cells

21 January 2018

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Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy

21 January 2018

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Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human gastric carcinoma.

21 January 2018

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Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human breast carcinoma

21 January 2018

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Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a prognostic factor in human endometrial carcinoma.

21 January 2018

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Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents

21 January 2018

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Immunohistochemical localization of metallothionein in benign and malignant epithelial ovarian tumors.

21 January 2018

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Expression of glutathione S-transferase pi (GST-pi) in human malignant ovarian tumors

21 January 2018

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Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas.

21 January 2018

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21 January 2018

TP53 and ovarian cancer

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Chemoresistance in human ovarian cancer: the role of apoptotic regulators

21 January 2018

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Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models

21 January 2018

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Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells

21 January 2018

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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

21 January 2018

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Taxol stabilizes microtubules in mouse fibroblast cells

21 January 2018

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21 January 2018

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The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

21 January 2018

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Docetaxel: an update of its use in advanced breast cancer

21 January 2018

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Paclitaxel. An update of its use in the treatment of metastatic breast cancer and ovarian and other gynaecological cancers

21 January 2018

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Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer.

21 January 2018

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Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer

21 January 2018

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Predictive factors for response to docetaxel in human breast cancers

21 January 2018

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Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel

21 January 2018

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Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours

21 January 2018

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Potential for improvement of docetaxel-based chemotherapy: a pharmacological review

21 January 2018

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Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer

21 January 2018

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Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein

21 January 2018

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beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.

21 January 2018

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Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules

21 January 2018

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Thermodynamics of ligand-induced assembly of tubulin.

21 January 2018

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Mutation of the class I beta-tubulin gene does not predict response to paclitaxel for breast cancer.

21 January 2018

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DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo

21 January 2018

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Vinflunine, a second generation novel Vinca Alkaloid with a distinctive pharmacological profile, now in clinical development and prospects for future mitotic blockers

21 January 2018

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Role of vindesine in induction chemotherapy in locally-advanced non-small-cell lung cancer

21 January 2018

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Antiproliferative activity of vinorelbine (Navelbine) against six human melanoma cell lines.

21 January 2018

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Vinorelbine--a clinical review

21 January 2018

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21 January 2018

Vinorelbine: an overview

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Developments in cytotoxic chemotherapy: advances in treatment utilising vinorelbine

21 January 2018

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Vinflunine: a new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy

21 January 2018

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Vinflunine, the latest Vinca alkaloid in clinical development. A review of its preclinical anticancer properties

21 January 2018

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Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumours

21 January 2018

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Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

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Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro

21 January 2018

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Markedly diminished drug resistance-inducing properties of vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro

21 January 2018

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21 January 2018

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From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates

21 January 2018

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Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro

21 January 2018

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Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells

21 January 2018

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Phenotypic Expression in Escherichia coli and Nucleotide Sequence of Two Chinese Hamster Lung Cell cDNAs Encoding Different Dihydrofolate Reductases

21 January 2018

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Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

21 January 2018

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Molecular basis of antifolate resistance

21 January 2018

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Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity

21 January 2018

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Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil

21 January 2018

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Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

21 January 2018

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Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response

21 January 2018

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Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up

21 January 2018

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Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.

21 January 2018

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In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant

21 January 2018

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Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer

21 January 2018

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Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells

21 January 2018

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Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits

21 January 2018

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Cellular roles of dna topoisomerases: a molecular perspective

21 January 2018

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Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

21 January 2018

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Topoisomerase I inhibitors: the relevance of prolonged exposure for present clinical development

21 January 2018

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Hematologic safety and tolerability of topotecan in recurrent ovarian cancer and small cell lung cancer: an integrated analysis

21 January 2018

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Irinotecan in the treatment of small cell lung cancer: a review of patient safety considerations

21 January 2018

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Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin

21 January 2018

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High-dose topotecan with granulocyte-colony stimulating factor in fluoropyrimidine-refractory colorectal cancer: a phase II and pharmacodynamic study.

21 January 2018

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Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

21 January 2018

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Determinants of CPT-11 and SN-38 activities in human lung cancer cells

21 January 2018

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Nonproductive rearrangement of DNA topoisomerase I and II genes: correlation with resistance to topoisomerase inhibitors.

21 January 2018

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Molecular basis of anthracycline-induced cardiotoxicity and its prevention

21 January 2018

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Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance.

21 January 2018

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MDR1/P-glycoprotein in haematological neoplasms

21 January 2018

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Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer

21 January 2018

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Changes of topoisomerase IIalpha expression in breast tumors after neoadjuvant chemotherapy predicts relapse-free survival.

21 January 2018

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Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000115967

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18 August 2017

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