(Q30444110)

20 August 2017

Multiscale, converging defects of macro-porosity, microstructure and matrix mineralization impact long bone fragility in NF1. (English)

1 reference

20 August 2017

1 reference

8

Nadine Kossler

0 references

Jirko Kühnisch

1

Jirko Kühnisch

1 reference

ORCID Public Data File 2021

Stefan Mundlos

22

Stefan Mundlos

1 reference

20 August 2017

Thaqif El Khassawna

16

0 references

Kay Raum

Kay Raum

20

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Peter Varga

Peter Varga

9

0 references

Peter Fratzl

Peter Fratzl

21

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author name string

Jong Seto

2

1 reference

20 August 2017

Claudia Lange

3

1 reference

20 August 2017

Susanne Schrof

4

1 reference

20 August 2017

Sabine Stumpp

5

1 reference

20 August 2017

Karolina Kobus

6

1 reference

20 August 2017

Julia Grohmann

7

1 reference

20 August 2017

Monika Osswald

10

1 reference

20 August 2017

Denise Emmerich

11

1 reference

20 August 2017

Sigrid Tinschert

12

1 reference

20 August 2017

Falk Thielemann

13

1 reference

20 August 2017

Georg Duda

14

1 reference

20 August 2017

Wenke Seifert

15

1 reference

20 August 2017

David A Stevenson

17

1 reference

20 August 2017

Florent Elefteriou

18

1 reference

20 August 2017

Uwe Kornak

19

1 reference

20 August 2017

Mateusz Kolanczyk

23

1 reference

20 August 2017

language of work or name

English

0 references

publication date

21 January 2014

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20 August 2017

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20 August 2017

9

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20 August 2017

1

1 reference

20 August 2017

e86115

1 reference

Creative Commons Attribution 4.0 International

20 August 2017

start time

21 January 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3897656/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation.

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Microfibril orientation dominates the microelastic properties of human bone tissue at the lamellar length scale.

20 June 2018

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Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

20 June 2018

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Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro

20 June 2018

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20 June 2018

Tumor endothelial cells

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Parathyroid hormone treatment improves the cortical bone microstructure by improving the distribution of type I collagen in postmenopausal women with osteoporosis

20 June 2018

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FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation

20 June 2018

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Animal models with pathological mineralization phenotypes

20 June 2018

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Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.

20 June 2018

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Neurofibromin (Nf1) is required for skeletal muscle development

20 June 2018

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Aberrant cAMP metabolism in NF1 malignant peripheral nerve sheath tumor cells

20 June 2018

1 reference

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New laboratory tools in the assessment of bone quality

20 June 2018

1 reference

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Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.

20 June 2018

1 reference

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20 June 2018

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Developmental abnormalities and cancer predisposition in neurofibromatosis type 1.

20 June 2018

1 reference

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Analysis of radiographic characteristics of anterolateral bowing of the leg before fracture in neurofibromatosis type 1.

20 June 2018

1 reference

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Normal bone anatomy and physiology

20 June 2018

1 reference

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Transcriptional regulation of osteoblasts

20 June 2018

1 reference

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Modelling neurofibromatosis type 1 tibial dysplasia and its treatment with lovastatin

20 June 2018

1 reference

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Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts.

20 June 2018

1 reference

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Assessment of anisotropic tissue elasticity of cortical bone from high-resolution, angular acoustic measurements.

20 June 2018

1 reference

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Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development

20 June 2018

1 reference

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ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae

20 June 2018

1 reference

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Cooperative deformation of mineral and collagen in bone at the nanoscale

20 June 2018

1 reference

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Bone strength: current concepts

20 June 2018

1 reference

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Bone quality--the material and structural basis of bone strength and fragility

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Cortical bone development under the growth plate is regulated by mechanical load transfer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Is osseous dysplasia a primary feature of neurofibromatosis 1 (NF1)?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Dentin matrix protein 1 immobilized on type I collagen fibrils facilitates apatite deposition in vitro.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

20 June 2018

1 reference

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The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Stiffness of compact bone: effects of porosity and density

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Are the polarization colors of picrosirius red-stained collagen determined only by the diameter of the fibers?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Bone structure: from angstroms to microns

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

Bone health and fracture rate in individuals with neurofibromatosis 1 (NF1).

20 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

Multiple roles for neurofibromin in skeletal development and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

Decreased bone mineral density in patients with neurofibromatosis 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

High bone turnover and accumulation of osteoid in patients with neurofibromatosis 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

The conflicts between strength and toughness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

Ultrastructural properties in cortical bone vary greatly in two inbred strains of mice as assessed by synchrotron light based micro- and nano-CT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

Osteopontin is an argentophilic protein in the bone matrix and in cells of kidney convoluted tubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

Spatial-temporal mapping of bone structural and elastic properties in a sheep model following osteotomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

Derivation of elastic stiffness from site-matched mineral density and acoustic impedance maps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

Fetal and postnatal mouse bone tissue contains more calcium than is present in hydroxyapatite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

Erk pathways negatively regulate matrix mineralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086115

21 January 2018

SnapShot: Ras Signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897656

A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells

26 November 2018

1 reference

12 December 2020

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction

1 reference

12 December 2020

Nanoscale Deformation Mechanisms in Bone

1 reference

12 December 2020

A method for preparing 2- to 50-micron-thick fresh-frozen sections of large samples and undecalcified hard tissues

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0086115

Identifiers

DOI

1 reference

20 August 2017

0 references

1 reference

20 August 2017

PubMed publication ID

24465906

1 reference