(Q30444760)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

title

Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

main subject

phase I clinical trial

0 references

1 reference

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

7

Patrick Y Wen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

8

Timothy F Cloughesy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

13

Larry Junck

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

1

Michael D Prados

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

16

John Kuhn

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

9

Susan M Chang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

14

Karen L Fink

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

15

Kenneth R Hess

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

3

Kurt A Jaeckle

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

author name string

W K A Yung

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

H Ian Robins

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

Howard A Fine

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

M Kelly Nicholas

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

David Schiff

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

Harry S Greenberg

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

North American Brain Tumor Consortium study

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

publication date

1 January 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

page(s)

44-54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

Multicentre phase II study and pharmacokinetic analysis of irinotecan in chemotherapy-naïve patients with glioblastoma

18 November 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Response and progression in recurrent malignant glioma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Phase I dose-finding and pharmacokinetic trial of irinotecan hydrochloride (CPT-11) using a once-every-three-week dosing schedule for patients with advanced solid tumor malignancy.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Irinotecan therapy in adults with recurrent or progressive malignant glioma.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871968

Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors

26 November 2018

1 reference

12 December 2020

Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions

1 reference

12 December 2020

Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters

1 reference

12 December 2020

Pharmacokinetic, metabolic, and pharmacodynamic profiles in a dose-escalating study of irinotecan and cisplatin

1 reference

12 December 2020

Proficient metabolism of irinotecan by a human intestinal carboxylesterase

1 reference

12 December 2020

In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone

1 reference

12 December 2020

The expression of UDP-glucuronosyltransferases of the UGT1 family in human liver and kidney and in response to drugs

1 reference

12 December 2020

Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital

1 reference

12 December 2020

10.1215/S1152851703000292

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14769140%20AND%20SRC:MED&resulttype=core&format=json

18 November 2019

PubMed publication ID

14769140

1 reference