(Q30445331)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Luis de Lecea

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

6

Joseph E Ledoux

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Robert M Sears

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Mattis B Wigestrand

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Claudia R Farb

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

language of work or name

English

0 references

publication date

25 November 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

1 March 2020

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

issue

50

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

20260-20265

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction

1 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Beta-adrenergic receptors in the lateral nucleus of the amygdala contribute to the acquisition but not the consolidation of auditory fear conditioning

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Tuning arousal with optogenetic modulation of locus coeruleus neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Optical activation of lateral amygdala pyramidal cells instructs associative fear learning

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Emotional enhancement of memory: how norepinephrine enables synaptic plasticity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Orexin receptor antagonists: a review of promising compounds patented since 2006.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Optogenetic deconstruction of sleep-wake circuitry in the brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

A key role for orexin in panic anxiety.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Dopamine spillover after quantal release: rethinking dopamine transmission in the nigrostriatal pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Locus coeruleus activation by foot shock or electrical stimulation inhibits amygdala neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Brain structures and receptors involved in alertness

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Experimental data on role of hypothalamus in mechanism of emotional behavior

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

CSF Norepinephrine Concentrations in Posttraumatic Stress Disorder

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Emotion circuits in the brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Neurons containing hypocretin (orexin) project to multiple neuronal systems

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Ascending projections of the locus coeruleus in the rat. II. Autoradiographic study

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons.

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Differential expression of orexin receptors 1 and 2 in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

A role for lateral hypothalamic orexin neurons in reward seeking

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Hypocretin/orexin contributes to the expression of some but not all forms of stress and arousal

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

The brain orexin system and almorexant in fear-conditioned startle reactions in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

SB-334867-A antagonises orexin mediated excitation in the locus coeruleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Behavioral correlates of activity in identified hypocretin/orexin neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Post-training injections of catecholaminergic drugs do not modulate fear conditioning in rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Orexin-A infusion in the locus ceruleus triggers norepinephrine (NE) release and NE-induced long-term potentiation in the dentate gyrus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Amygdala dysfunction in narcolepsy-cataplexy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Reduced amygdala activity during aversive conditioning in human narcolepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320325110

Emotional behavior produced by hypothalamic stimulation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Conditioned and unconditional components of post-shock freezing.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864341

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24277819

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1320325110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24277819%20AND%20SRC:MED&resulttype=core&format=json