(Q30454017)

21 June 2017

title

Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange (English)

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21 June 2017

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3

Michael R Shirts

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21 June 2017

Aming Zhang

1

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21 June 2017

Satish K Singh

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2

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21 June 2017

Sandeep Kumar

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4

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21 June 2017

Erik J Fernandez

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5

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21 June 2017

publication date

30 July 2011

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21 June 2017

published in

Pharmaceutical Research

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21 June 2017

volume

29

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21 June 2017

issue

1

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21 June 2017

page(s)

236-250

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Antibody structure, instability, and formulation

21 June 2017

cites work

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https://api.crossref.org/works/10.1007%2FS11095-011-0538-Y

Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity

21 January 2018

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Challenges in the development of high protein concentration formulations

21 January 2018

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Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice

21 January 2018

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Effects of protein aggregates: an immunologic perspective

21 January 2018

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The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein

21 January 2018

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The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies

21 January 2018

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Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity

21 January 2018

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Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments

21 January 2018

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Elucidation of two major aggregation pathways in an IgG2 antibody

21 January 2018

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Structure-immunogenicity relationships of therapeutic proteins

21 January 2018

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Cold denaturation of staphylococcal nuclease

21 January 2018

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Effect of mannitol crystallinity on the stabilization of enzymes during freeze-drying.

21 January 2018

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Probing the non-covalent structure of proteins by amide hydrogen exchange and mass spectrometry

21 January 2018

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Hydrogen/deuterium exchange mass spectrometry--a window into amyloid structure

21 January 2018

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21 January 2018

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

21 January 2018

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21 January 2018

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

21 January 2018

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Aggregation-prone motifs in human immunoglobulin G.

21 January 2018

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21 January 2018

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21 January 2018

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A new approach to explore the impact of freeze-thaw cycling on protein structure: hydrogen/deuterium exchange mass spectrometry (HX-MS).

21 January 2018

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Proteins in frozen solutions: evidence of ice-induced partial unfolding

21 January 2018

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Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies.

21 January 2018

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Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.

21 January 2018

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Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

21 January 2018

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Prediction of amyloidogenic and disordered regions in protein chains

21 January 2018

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Consensus prediction of amyloidogenic determinants in amyloid fibril-forming proteins.

21 January 2018

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Sequence determinants of amyloid fibril formation

21 January 2018

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Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential

21 January 2018

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Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry

21 January 2018

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Stability of protein pharmaceuticals: an update

21 January 2018

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A broad range of Fab stabilities within a host of therapeutic IgGs.

21 January 2018

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Surface-induced denaturation of proteins during freezing and its inhibition by surfactants

21 January 2018

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12 December 2020

Construction and characterization of an NaCl-sensitive mutant of Halomonas elongata impaired in ectoine biosynthesis

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12 December 2020

Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress

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12 December 2020

Salt precipitation during the freeze-concentration of phosphate buffer solutions

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12 December 2020

Pharmaceutical applications of isoelectric focusing on microchip with imaged UV detection

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12 December 2020

10.1007/S11095-011-0538-Y

Identifiers

DOI

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21 June 2017

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