(Q30484122)

English

Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment

scientific article

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scholarly article

1 reference

Europe PubMed Central

16 October 2017

Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment (English)

1 reference

Europe PubMed Central

16 October 2017

steatohepatitis

0 references

type 2 diabetes

1 reference

based on heuristic

inferred from title

non-alcoholic steatohepatitis

1 reference

based on heuristic

inferred from title

cognitive dysfunction

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

author name string

Suzanne M de la Monte

1

1 reference

Europe PubMed Central

16 October 2017

Ming Tong

2

1 reference

Europe PubMed Central

16 October 2017

Margot Lawton

3

1 reference

Europe PubMed Central

16 October 2017

Lisa Longato

4

1 reference

Europe PubMed Central

16 October 2017

publication date

24 December 2009

1 reference

Europe PubMed Central

16 October 2017

Molecular Neurodegeneration

1 reference

Europe PubMed Central

16 October 2017

4

1 reference

Europe PubMed Central

16 October 2017

54

1 reference

Europe PubMed Central

16 October 2017

https://scigraph.springernature.com/pub.10.1186/1750-1326-4-54

0 references

Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease

1 reference

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20 June 2018

Alzheimer's disease is type 3 diabetes-evidence reviewed

1 reference

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20 June 2018

Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine

1 reference

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20 June 2018

Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis

1 reference

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20 June 2018

Mechanisms of ceramide-mediated neurodegeneration

1 reference

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20 June 2018

Epidemilogical trends strongly suggest exposures as etiologic agents in the pathogenesis of sporadic Alzheimer's disease, diabetes mellitus, and non-alcoholic steatohepatitis.

1 reference

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20 June 2018

Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus.

1 reference

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20 June 2018

Altered lipid metabolism in brain injury and disorders

1 reference

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20 June 2018

Free fatty acids and skeletal muscle insulin resistance

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20 June 2018

Alzheimer's disease: epidemiology, genetics, and beyond

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20 June 2018

Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

1 reference

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20 June 2018

Evolving trends in nonalcoholic fatty liver disease

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20 June 2018

Obesity, metabolic syndrome, and type 2 diabetes: inflammatory basis of glucose metabolic disorders

1 reference

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20 June 2018

Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes

1 reference

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20 June 2018

Nonalcoholic fatty liver disease and mitochondrial dysfunction

1 reference

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20 June 2018

Non-alcoholic fatty liver disease and the metabolic syndrome: an update

1 reference

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20 June 2018

Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate

1 reference

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20 June 2018

Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes

1 reference

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20 June 2018

Pathology of nonalcoholic fatty liver disease

1 reference

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20 June 2018

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons

1 reference

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20 June 2018

Evaluation and management of obesity-related nonalcoholic fatty liver disease

1 reference

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20 June 2018

Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model

1 reference

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20 June 2018

Lipid mediators of insulin resistance

1 reference

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20 June 2018

Role of mitochondria in non-alcoholic fatty liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Metabolic syndrome and NASH.

1 reference

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20 June 2018

Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study

1 reference

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20 June 2018

Update on non-alcoholic fatty liver disease in children

1 reference

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20 June 2018

Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease

1 reference

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20 June 2018

Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Next steps in Alzheimer's disease research: interaction between epidemiology and basic science

1 reference

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20 June 2018

Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease

1 reference

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20 June 2018

Insulin resistance as a membrane microdomain disorder

1 reference

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20 June 2018

Intranasal insulin administration: a method for dissociating central and peripheral effects of insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Diabetes mellitus and dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Nonalcoholic steatohepatitis--a histological perspective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Ceramides in insulin resistance and lipotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Studies of the effects of high fat diets on cognitive function in a rat model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Maximizing outcome of dementia treatment: the role of nutrition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Genotoxicity of streptozotocin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Diabetic neuropathies in brain are induced by deficiency of BDNF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Radicals and oxidative stress in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Site-specific DNA methylation and apoptosis: induction by diabetogenic streptozotocin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Evidence for multiple causality in the development of diabetic hypertriglyceridaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Induction of carcinogenesis in Fischer rats by methylalkylnitrosamines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Spectrofluorometric studies of the lipid probe, nile red.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Application of Nile red, a fluorescent hydrophobic probe, for the detection of neutral lipid deposits in tissue sections: comparison with oil red O.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Studies on the Mechanism of the Diabetogenic Activity of Streptozotocin and on the Ability of Compounds to Block the Diabetogenic Activity of Streptozotocin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

Studies of streptozotocin-induced insulitis and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

20 June 2018

The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

26 November 2018

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

26 November 2018

Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

26 November 2018

Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

26 November 2018

Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

26 November 2018

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

1 reference

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26 November 2018

Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

26 November 2018

Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease

1 reference

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26 November 2018

Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver

1 reference

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26 November 2018

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype

1 reference

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26 November 2018

Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

26 November 2018

Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803782

26 November 2018

Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection.

1 reference

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26 November 2018

Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761).

1 reference

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26 November 2018

Brain glutamate dehydrogenase changes in streptozotocin diabetic rats as a function of age.

1 reference

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26 November 2018

Use of the Morris water maze and acoustic startle chamber to evaluate neurologic injury after asphyxial arrest in rats.

1 reference

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26 November 2018

Age, education, and changes in the Mini-Mental State Exam scores of older women: findings from the Nun Study.

1 reference

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26 November 2018

Pancreatic islet hypertrophy in spontaneous maturity onset obese-diabetic CBA/Ca mice.

1 reference

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26 November 2018

Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate

1 reference

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26 November 2018

Mechanisms of fat-related modulation of N-nitrosodiethylamine-induced tumors in rats: organ distribution, blood lipids, enzymes and pro-oxidant state

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diethylnitrosamine oncogenesis in RF mice as influenced by variations in cumulative dose

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liposolubility as an aspect of nitrosamine carcinogenicity: Quantitative correlations and qualitative observations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose response studies of carcinogenesis in rats by nitrosodiethylamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From disease-oriented to aging/longevity-oriented studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement by streptozotocin of O2- radical generation by the xanthine oxidase system of pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism of N-nitrosomethylaniline

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lethal forebrain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic complications in a new animal model (TSOD mouse) of spontaneous NIDDM with obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haemoglobin adducts as biomarkers of exposure to tobacco-related nitrosamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20034403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1750-1326-4-54

1 reference

Europe PubMed Central

16 October 2017

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1750-1326-4-54

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

ResearchGate publication ID

0 references

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