(Q36512147)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

review article

1 reference

title

Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

main subject

Alzheimer's disease

0 references

cardiovascular disease

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Sandra I Sünram-Lea

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

author name string

I J Martins

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

J K Foster

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

A Gnjec

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

S J Fuller

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

D Nolan

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

S E Gandy

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

R N Martins

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

language of work or name

English

0 references

publication date

20 June 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

page(s)

721-736

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16786033%20AND%20SRC:MED&resulttype=core&format=json

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

25 December 2019

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Gender differences on a brief measure of cognitive functioning in Alzheimer's disease.

21 January 2018

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Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center

21 January 2018

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Amyloid and lipids in the pathology of Alzheimer disease.

21 January 2018

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Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

21 January 2018

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LRP and Alzheimer's disease

21 January 2018

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Cognitive decline and Japanese culture in a cohort of older Japanese Americans in King County, WA: the Kame Project

21 January 2018

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Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study

21 January 2018

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Positron emission tomography in Alzheimer's disease

21 January 2018

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Hyperinsulinemia and risk of Alzheimer disease.

21 January 2018

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Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

21 January 2018

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The conflicting role of brain cholesterol in Alzheimer's disease: lessons from the brain plasminogen system

21 January 2018

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Future scenarios for the prevention and delay of Alzheimer disease onset in high-risk groups. An ethical perspective

21 January 2018

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7 January 2021

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.

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7 January 2021

The spectrum of behavioral changes in Alzheimer's disease.

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7 January 2021

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7 January 2021

The genetics of Alzheimer's disease

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7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

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7 January 2021

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.

1 reference

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7 January 2021

Two novel presenilin-1 mutations (Ser169Leu and Pro436Gln) associated with very early onset Alzheimer's disease.

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7 January 2021

Exploring the etiology of Alzheimer disease using molecular genetics

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7 January 2021

Epidemiology of clinically diagnosed Alzheimer's disease

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7 January 2021

Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

1 reference

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7 January 2021

Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study

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7 January 2021

An 18-year follow-up of overweight and risk of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Type 2 diabetes mellitus, cognitive impairment and dementia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population.

1 reference

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7 January 2021

Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias

1 reference

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7 January 2021

The prevalence of dementia and Alzheimer's disease in Shanghai, China: impact of age, gender, and education

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7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

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7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

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7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

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7 January 2021

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

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7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

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7 January 2021

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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7 January 2021

Alzheimer disease: curly fibers and tangles in organs other than brain.

1 reference

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7 January 2021

Link between heart disease, cholesterol, and Alzheimer's disease: a review

1 reference

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7 January 2021

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels

1 reference

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7 January 2021

Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease.

1 reference

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7 January 2021

Raising high-density lipoprotein cholesterol: innovative strategies against an old adversary

1 reference

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7 January 2021

A seed for Alzheimer amyloid in the brain.

1 reference

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7 January 2021

Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques

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7 January 2021

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation

1 reference

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7 January 2021

The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease.

1 reference

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7 January 2021

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

1 reference

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7 January 2021

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

1 reference

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7 January 2021

Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease.

1 reference

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7 January 2021

APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease

1 reference

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7 January 2021

Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

CNS synaptogenesis promoted by glia-derived cholesterol

1 reference

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7 January 2021

22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Transcription-dependent degradation controls the stability of the SREBP family of transcription factors.

1 reference

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7 January 2021

Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 allele

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

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7 January 2021

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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7 January 2021

Neuronal membrane cholesterol loss enhances amyloid peptide generation

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7 January 2021

1 reference

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7 January 2021

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase

1 reference

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7 January 2021

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

1 reference

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7 January 2021

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

1 reference

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7 January 2021

Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein

1 reference

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7 January 2021

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

1 reference

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7 January 2021

Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Statins and the risk of dementia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Clinical pharmacology of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

1 reference

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7 January 2021

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Statin therapy for Alzheimer's disease: will it work?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Lipoprotein lipase mutations and Alzheimer's disease

1 reference

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7 January 2021

Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits

1 reference

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7 January 2021

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase

1 reference

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7 January 2021

Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana

1 reference

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7 January 2021

Diet and risk of dementia: Does fat matter?: The Rotterdam Study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Brain region-dependent increases in beta-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Cholesterol and cognition: rationale for the AD cholesterol-lowering treatment trial and sex-related Differences in beta-amyloid accumulation in the brains of spontaneously hypercholesterolemic Watanabe rabbits

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

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7 January 2021

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

1 reference

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7 January 2021

High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs.

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7 January 2021

Learning and memory impairment in rats fed a high saturated fat diet

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7 January 2021

Cognitive impairment in rats fed high-fat diets: a specific effect of saturated fatty-acid intake

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7 January 2021

The effects of high fat diets and environmental influences on cognitive performance in rats

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7 January 2021

Can dementia be prevented? Brain aging in a population-based context

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7 January 2021

Plasma Abeta42 correlates positively with increased body fat in healthy individuals.

1 reference

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7 January 2021

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Dietary lipids influence insulin action.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Does dietary fat influence insulin action?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Effects of dietary fatty acids on insulin sensitivity and secretion

1 reference

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7 January 2021

Diabetogenic impact of long-chain omega-3 fatty acids on pancreatic beta-cell function and the regulation of endogenous glucose production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

High saturated fat and low starch and fibre are associated with hyperinsulinaemia in a non-diabetic population: the San Luis Valley Diabetes Study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Association of diabetes mellitus and dementia: the Rotterdam Study.

1 reference

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7 January 2021

Increased risk of type 2 diabetes in Alzheimer disease

1 reference

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7 January 2021

Cognitive impairment, physical disability and depressive symptoms in older diabetic patients: the Fremantle Cognition in Diabetes Study.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Diabetes mellitus is a risk factor for vascular dementia, but not for Alzheimer's disease: a population-based study of the oldest old.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Obesity and post-prandial lipid metabolism. Feast or famine?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Diabetes contributes to cholesterol metabolism regardless of obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Diabetes, Alzheimer's disease and apolipoprotein genotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

PET studies in dementia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Glucose and memory in mild senile dementia of the Alzheimer type

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Peripheral glucose metabolism and insulin sensitivity in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Blood glucose and insulin response in patients with senile dementia of the Alzheimer's type

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: a longitudinal study.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer's type.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

The effect of insulin and glucose on the plasma concentration of Alzheimer's amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Serum or cerebrospinal fluid levels of glyceraldehyde-derived advanced glycation end products (AGEs) may be a promising biomarker for early detection of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Role of insulin and insulin receptor in learning and memory

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Signaling by insulin-like growth factor 1 in brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Distribution and levels of [125I]IGF-I, [125I]IGF-II and [125I]insulin receptor binding sites in the hippocampus of aged memory-unimpaired and -impaired rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoproteins in human cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Cholesterol homeostasis in neurons and glial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Genetic dissection of Alzheimer disease, a heterogeneous disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Interactions of apolipoprotein E genotype and dietary fat intake of healthy older persons during mid-adult life.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Biochemical and cognitive studies of apolipoprotein-E-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Brain area- and isoform-specific inhibition of synaptic plasticity by apoE4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Human apolipoprotein E accelerates microtubule polymerization in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

The challenge of characterizing normal brain aging in relation to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Intracellular apolipoprotein E affects Amyloid Precursor Protein processing and amyloid Abeta production in COS-1 cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Clearing amyloid through the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

Neuroprotective signaling and the aging brain: take away my food and let me run.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

The significance of environmental factors in the etiology of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021

The role of diet in cognitive decline

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001854

7 January 2021