(Q30485126)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

title

FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

author name string

Sasha F Levy

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Michelle Gaylord

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Arnab Bhattacharya

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Ambuj K Singh

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Mary Ann Jordan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Leslie Wilson

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Stuart C Feinstein

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

language of work or name

English

0 references

publication date

21 October 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

24 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

volume

283

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

issue

52

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

page(s)

36406-36415

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

A general modeling and visualization tool for comparing different members of a group: application to studying tau-mediated regulation of microtubule dynamics.

24 December 2019

cites work

1 reference

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A century of Alzheimer's disease

20 June 2018

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Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

20 June 2018

1 reference

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Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

20 June 2018

1 reference

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Tau suppression in a neurodegenerative mouse model improves memory function

20 June 2018

1 reference

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Tau phosphorylation: physiological and pathological consequences

20 June 2018

1 reference

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Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death

20 June 2018

1 reference

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Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases

20 June 2018

1 reference

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Microtubules as a target for anticancer drugs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Modeling tau polymerization in vitro: a review and synthesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Tau gene mutations: dissecting the pathogenesis of FTDP-17.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Filopodia and actin arcs guide the assembly and transport of two populations of microtubules with unique dynamic parameters in neuronal growth cones

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Neurodegenerative tauopathies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Tau gene mutation K257T causes a tauopathy similar to Pick's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Fibrillogenesis of tau: insights from tau missense mutations in FTDP-17.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Taxol suppresses dynamics of individual microtubules in living human tumor cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

The distribution of tau in the mammalian central nervous system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Developmentally regulated expression of specific tau sequences

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

The microtubule binding domain of tau protein.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Tau protein binds to microtubules through a flexible array of distributed weak sites

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Microtubule dynamics in axons and dendrites

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Microtubule assembly in vitro. Purification of assembly-promoting factors.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606000

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

Three- and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in qualitatively different manners. Implications for neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

Untangling memory deficits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803519200

FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10

21 January 2018

1 reference

12 December 2020

Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations

1 reference

12 December 2020

Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments

1 reference

12 December 2020

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

1 reference

12 December 2020

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

1 reference

12 December 2020

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M803519200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18940799%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

18940799

1 reference