(Q30488706)

18 August 2017

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity (English)

1 reference

18 August 2017

1 reference

6

Erik C Böttger

1 reference

18 August 2017

Sven N Hobbie

1

1 reference

18 August 2017

Subramanian Akshay

2

1 reference

18 August 2017

Sarath K Kalapala

3

1 reference

18 August 2017

Christian M Bruell

4

1 reference

18 August 2017

Dmitry Shcherbakov

5

1 reference

18 August 2017

language of work or name

English

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publication date

22 December 2008

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Proceedings of the National Academy of Sciences of the United States of America

18 August 2017

1 reference

18 August 2017

105

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18 August 2017

52

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18 August 2017

20888-20893

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describes a project that uses

18 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2634874/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates

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Mitochondrial deafness alleles confer misreading of the genetic code

20 June 2018

1 reference

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Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria

20 June 2018

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Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic

20 June 2018

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A genetic model to investigate drug-target interactions at the ribosomal decoding site

20 June 2018

1 reference

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Aspirin to prevent gentamicin-induced hearing loss

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA.

20 June 2018

1 reference

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Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity.

20 June 2018

1 reference

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Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Defining the basis for the specificity of aminoglycoside-rRNA recognition: a comparative study of drug binding to the A sites of Escherichia coli and human rRNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Sensory hair cell death and regeneration: two halves of the same equation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Maternally inherited aminoglycoside-induced and nonsyndromic deafness is associated with the novel C1494T mutation in the mitochondrial 12S rRNA gene in a large Chinese family

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

The Molecular Basis for A‐Site Mutations Conferring Aminoglycoside Resistance: Relationship between Ribosomal Susceptibility and X‐ray Crystal Structures

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Aminoglycoside resistance with homogeneous and heterogeneous populations of antibiotic-resistant ribosomes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Structural basis for selectivity and toxicity of ribosomal antibiotics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Aminoglycoside antibiotics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Basis for prokaryotic specificity of action of aminoglycoside antibiotics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Mitochondrial deafness mutations reviewed

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

RecA-Mediated gene conversion and aminoglycoside resistance in strains heterozygous for rRNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Familial progressive sensorineural deafness is mainly due to the mtDNA A1555G mutation and is enhanced by treatment of aminoglycosides

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Introducing mutations into a chromosomal rRNA gene using a genetically modified eubacterial host with a single rRNA operon.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Proposed molecular and cellular mechanism for aminoglycoside ototoxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Interaction of antibiotics with functional sites in 16S ribosomal RNA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Mutations in 16S ribosomal RNA disrupt antibiotic--RNA interactions.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Effects of mutagenesis of a conserved base-paired site near the decoding region of Escherichia coli 16 S ribosomal RNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Functional interaction of neomycin B and related antibiotics with 30S and 50S ribosomal subunits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Direct chemical method for sequencing RNA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634874

Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811258106

Monitoring molecular recognition of the ribosomal decoding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811258106

Aminoglycoside binding to human and bacterial A-Site rRNA decoding region constructs

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811258106

Mutagenesis of 16S rRNA C1409-G1491 base-pair differentiates between 6'OH and 6'NH3+ aminoglycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811258106

Decoding region bubble size and aminoglycoside antibiotic binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811258106

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811258106

Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811258106

Specific binding of aminoglycosides to a human rRNA construct based on a DNA polymorphism which causes aminoglycoside-induced deafness

21 January 2018

1 reference

12 December 2020

Misreading of RNA codewords induced by aminoglycoside antibiotics

1 reference

12 December 2020

Fidelity of protein synthesis with chicken embryo mitochondrial and cytoplasmic ribosomes

1 reference

12 December 2020

Ototoxicity in vitro: effects of neomycin, gentamicin, dihydrostreptomycin, amikacin, spectinomycin, neamine, spermine and poly-L-lysine

1 reference

12 December 2020

Aminoglycosides--50 years on

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0811258106

1 reference

18 August 2017

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18 August 2017

1 reference