(Q30497031)

13 October 2017

The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase (English)

1 reference

13 October 2017

Piyawan Bunpo

1

1 reference

13 October 2017

Judy K Cundiff

2

1 reference

13 October 2017

Rachel B Reinert

3

1 reference

13 October 2017

Ronald C Wek

4

1 reference

13 October 2017

Carla J Aldrich

5

1 reference

13 October 2017

Tracy G Anthony

6

1 reference

13 October 2017

language of work or name

English

0 references

publication date

22 September 2010

1 reference

13 October 2017

1 reference

13 October 2017

140

1 reference

13 October 2017

11

1 reference

13 October 2017

2020-2027

1 reference

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Growing rats respond to a sulfur amino acid-deficient diet by phosphorylation of the alpha subunit of eukaryotic initiation factor 2 heterotrimeric complex and induction of adaptive components of the integrated stress response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

ATF4-dependent transcription mediates signaling of amino acid limitation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Blocking UV-induced eIF2alpha phosphorylation with small molecule inhibitors of GCN2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Critical roles of glutamine as nitrogen donors in purine and pyrimidine nucleotide synthesis: asparaginase treatment in childhood acute lymphoblastic leukemia.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Expression levels of asparagine synthetase in blasts from children and adults with acute lymphoblastic leukaemia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Treatment of acute lymphoblastic leukemia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Coping with stress: eIF2 kinases and translational control

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

The thymus: a barometer of malnutrition.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Glutamine requirement of proliferating T lymphocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Enzyme-induced asparagine and glutamine depletion and immune system function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

The essential role of L-glutamine in lymphocyte differentiation in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Asparaginase-induced derangements of glutamine metabolism: the pathogenetic basis for some drug-related side-effects.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

The inhibition of lymphocyte blastogenesis by asparaginase: critical role of glutamine in both T and B lymphocyte transformation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells

20 June 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Alanyl-glutamine consumption modifies the suppressive effect of L-asparaginase on lymphocyte populations in mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961).

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Glutamine and glucose metabolism in rat splenocytes and mesenteric lymph node lymphocytes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Alteration in spleen lymphoid populations associated with specific amino acid depletion during L-asparaginase treatment

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20861212

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kinetic analysis of hepatotoxicity associated with antineoplastic asparaginases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20861212

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3945/JN.110.129197

1 reference

13 October 2017

1 reference

13 October 2017

1 reference