(Q30497111)

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Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20705605%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20705605%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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alpha,alpha-trehalose

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spinocerebellar ataxia type 14

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based on heuristic

inferred from title

Takahiro Kikawada

3

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9 February 2020

1

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9 February 2020

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9 February 2020

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9 February 2020

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Norio Sakai

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9 February 2020

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Izumi Hide

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9 February 2020

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Nana Abe-Seki

2

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9 February 2020

Hideyuki Takahashi

4

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9 February 2020

Kazuhiro Yamamoto

5

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9 February 2020

Naoaki Saito

9

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9 February 2020

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12 August 2010

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9 February 2020

Journal of Biological Chemistry

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9 February 2020

285

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9 February 2020

43

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9 February 2020

33252-33264

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20705605%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Trehalose impairs aggregation of PrPSc molecules and protects prion-infected cells against oxidative damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Protection from ataxia-linked apoptosis by gap junction inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Trehalose transporter 1, a facilitated and high-capacity trehalose transporter, allows exogenous trehalose uptake into cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Trehalose as a "chemical chaperone": fact and fantasy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

The natural osmolyte trehalose is a positive regulator of the heat-induced activity of yeast heat shock transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Fused protein of deltaPKC activation loop and PDK1-interacting fragment (deltaAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Molecular pathogenesis of spinocerebellar ataxias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

SCA28, a novel form of autosomal dominant cerebellar ataxia on chromosome 18p11.22-q11.2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Trinucleotide repeats and neurodegenerative disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Protein aggregation and neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Protein misfolding in neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Toxic proteins in neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Molecular basis of the neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Multiple effects of trehalose on protein folding in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

The metabolism of alpha,alpha-trehalose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Distribution of protein kinase C-like immunoreactive neurons in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

20 June 2018

Novel PRKCG/SCA14 mutation in a Dutch spinocerebellar ataxia family: expanding the phenotype.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Trehalose-protein interaction in aqueous solution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Trehalose uptake through P2X7 purinergic channels provides dehydration protection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

The clinical and genetic spectrum of spinocerebellar ataxia 14

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Loading Human Mesenchymal Stem Cells with Trehalose by Fluid-Phase Endocytosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Another Mutation in Cysteine 131 in Protein Kinase Cγ as a Cause of Spinocerebellar Ataxia Type 14

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.146704

21 January 2018

Mechanism allowing an insect to survive complete dehydration and extreme temperatures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963337

26 November 2018

Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/20705605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the highly conserved cysteine residue 131 of the SCA14 associated PRKCG gene in a family with slow progressive cerebellar ataxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20705605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinocerebellar ataxia 14: novel mutation in exon 2 of PRKCG in a German family

1 reference

https://pubmed.ncbi.nlm.nih.gov/20705605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trehalose effects on alpha-crystallin aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20705605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benign SCA14 phenotype in a German patient associated with a missense mutation in exon 3 of the PRKCG gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/20705605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.146704

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20705605%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20705605%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20705605%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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