(Q30499131)

19 October 2017

Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome (English)

1 reference

19 October 2017

5

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19 October 2017

10

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19 October 2017

Francisca Mulero

8

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author name string

Jelena Urosevic

1

1 reference

19 October 2017

Vincent Sauzeau

2

1 reference

19 October 2017

María L Soto-Montenegro

3

1 reference

19 October 2017

Santiago Reig

4

1 reference

19 October 2017

Emma M Burkitt Wright

6

1 reference

19 October 2017

Marta Cañamero

7

1 reference

19 October 2017

Sagrario Ortega

9

1 reference

19 October 2017

Mariano Barbacid

11

1 reference

19 October 2017

language of work or name

English

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publication date

7 March 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

19 October 2017

1 reference

19 October 2017

108

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19 October 2017

12

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19 October 2017

5015-5020

1 reference

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

19 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Oncogenic Braf induces melanocyte senescence and melanoma in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Hyperactive Ras in developmental disorders and cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

The cardiofaciocutaneous syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Germline mutations in HRAS proto-oncogene cause Costello syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Astrocyte activation and reactive gliosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

The RAF proteins take centre stage

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Pheochromocytoma: the expanding genetic differential diagnosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Mutations of the BRAF gene in human cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Repeated seizures increase GFAP and vimentin in the hippocampus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064394

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016933108

Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016933108

Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016933108

Further delineation of cardio-facio-cutaneous syndrome: clinical features of 38 individuals with proven mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016933108

Noonan and cardio-facio-cutaneous syndromes: two clinically and genetically overlapping disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016933108

Further delineation of the phenotype resulting from BRAF or MEK1 germline mutations helps differentiate cardio-facio-cutaneous syndrome from Costello syndrome

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21383153

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1016933108

1 reference

19 October 2017

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1 reference

19 October 2017

1 reference