(Q30500731)

13 October 2017

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice (English)

1 reference

13 October 2017

1 reference

14

0 references

Hermann Pavenstädt

16

0 references

Dontscho Kerjaschki

17

object named as

Dontscho Kerjaschki

0 references

Nadja Herbach

3

object named as

Nadja Herbach

1 reference

13 October 2017

Rüdiger Wanke

15

0 references

Tobias B Huber

object named as

Tobias B Huber

23

1 reference

ORCID Public Data File 2021

author name string

Markus Gödel

1

1 reference

13 October 2017

Björn Hartleben

2

1 reference

13 October 2017

Shuya Liu

4

1 reference

13 October 2017

Stefan Zschiedrich

5

1 reference

13 October 2017

Shun Lu

6

1 reference

13 October 2017

Andrea Debreczeni-Mór

7

1 reference

13 October 2017

Maja T Lindenmeyer

8

1 reference

13 October 2017

Maria-Pia Rastaldi

9

1 reference

13 October 2017

Götz Hartleben

10

1 reference

13 October 2017

Thorsten Wiech

11

1 reference

13 October 2017

Alessia Fornoni

12

1 reference

13 October 2017

Robert G Nelson

13

1 reference

13 October 2017

Clemens D Cohen

18

1 reference

13 October 2017

Michael N Hall

19

1 reference

13 October 2017

Markus A Rüegg

20

1 reference

13 October 2017

Ken Inoki

21

1 reference

13 October 2017

Gerd Walz

22

1 reference

13 October 2017

language of work or name

English

0 references

publication date

23 May 2011

1 reference

Journal of Clinical Investigation

13 October 2017

1 reference

13 October 2017

121

1 reference

13 October 2017

6

1 reference

13 October 2017

2197-2209

1 reference

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The story of Notch and chronic kidney disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Insulin signaling to the glomerular podocyte is critical for normal kidney function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The role of the mammalian target of rapamycin (mTOR) in renal disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Significance and management of proteinuria in kidney transplant recipients

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

mTOR signaling at a glance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Nck proteins maintain the adult glomerular filtration barrier

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

mTOR and the control of whole body metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Role of TSC-mTOR pathway in diabetic nephropathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Tuberous sclerosis complex proteins control axon formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

VEGF inhibition and renal thrombotic microangiopathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

A global double-fluorescent Cre reporter mouse

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

TOR signaling in growth and metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Insulin-like growth factor binding protein 2 (IGFBP-2) separates hypertrophic and hyperplastic effects of growth hormone (GH)/IGF-I excess on adrenocortical cells in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

A new method for large scale isolation of kidney glomeruli from mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Diabetic nephropathy: pathogenesis, diagnosis, and prevention of progression.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The sizes of renal glomeruli in fetuses and infants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The pathophysiology of protein-overload proteinuria.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Role of growth hormone in the development of experimental renal scarring

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Glomerular size and structure in diabetes mellitus. I. Early abnormalities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Tubular epithelial cell and podocyte apoptosis with de novo sirolimus based immunosuppression in renal allograft recipients with DGF.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The Notch pathway in podocytes plays a role in the development of glomerular disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Post-transplantation proteinuria and sirolimus

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Podocyte-specific expression of cre recombinase in transgenic mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Drosophila S6 kinase: a regulator of cell size

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Mammalian Target of Rapamycin Pathway Blockade Slows Progression of Diabetic Kidney Disease in Rats

26 November 2018

1 reference

12 December 2020

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model

1 reference

12 December 2020

Renoprotective effects of sirolimus in non-immune initiated focal segmental glomerulosclerosis

1 reference

12 December 2020

High sirolimus levels may induce focal segmental glomerulosclerosis de novo

1 reference

12 December 2020

Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application

1 reference

12 December 2020

The unbiased estimation of number and sizes of arbitrary particles using the disector

1 reference

12 December 2020

Stereological estimates of volume-weighted mean glomerular volume in streptozotocin-diabetic rats

1 reference

12 December 2020

Large juxtamedullary glomeruli and afferent arterioles in healthy primates

1 reference

12 December 2020

A principle for counting tissue structures on random sections

1 reference

12 December 2020

Heparan sulfate of perlecan is involved in glomerular filtration

1 reference

12 December 2020

Determinants of Glomerular Volume in Different Cortical Zones of the Human Kidney

1 reference

12 December 2020

Role of podocytes in focal sclerosis: defining the point of no return

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI44774

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

21606591

1 reference