(Q30500880)

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IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.

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20 January 2020

IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation (English)

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20 January 2020

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ChEBI release 2020-05-28

apoptotic process

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based on heuristic

inferred from title

David M. Virshup

7

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20 January 2020

3

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20 January 2020

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J K Cheong

1

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20 January 2020

T H Nguyen

2

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20 January 2020

P Tan

4

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20 January 2020

P M Voorhoeve

5

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20 January 2020

S H Lee

6

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20 January 2020

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24 January 2011

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20 January 2020

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Europe PubMed Central

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20 January 2020

30

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20 January 2020

22

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20 January 2020

2558-2569

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Europe PubMed Central

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20 January 2020

Microtubule-destabilizing agents: structural and mechanistic insights from the interaction of colchicine and vinblastine with tubulin.

1 reference

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20 June 2018

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

1 reference

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CK1epsilon is required for breast cancers dependent on beta-catenin activity

1 reference

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The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent

1 reference

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20 June 2018

Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period

1 reference

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Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity

1 reference

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20 June 2018

DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.

1 reference

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20 June 2018

Kinase requirements in human cells: I. Comparing kinase requirements across various cell types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Reversible protein phosphorylation regulates circadian rhythms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Human cancer cells commonly acquire DNA damage during mitotic arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

The selectivity of protein kinase inhibitors: a further update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.

1 reference

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20 June 2018

Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Casein kinase I: from obscurity to center stage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

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1 reference

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An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Crystal structure of a conformation-selective casein kinase-1 inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

P53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints

1 reference

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Cluster analysis and display of genome-wide expression patterns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

20 June 2018

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109269

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Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle

1 reference

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1 reference

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Identification of a new family of protein phosphatase 2A regulatory subunits

1 reference

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20 June 2018

Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo

1 reference

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"Promiscuous" anticancer drugs that hit multiple targets may thwart resistance.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.627

21 January 2018

Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.627

21 January 2018

Casein kinase I transduces Wnt signals

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.627

21 January 2018

Inhibition of casein kinase I epsilon/delta produces phase shifts in the circadian rhythms of Cynomolgus monkeys.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.627

21 January 2018

The tumor-suppressive functions of the human INK4A locus

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.627

21 January 2018

IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.627

31 March 2020

Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.627

31 March 2020

Species- and cell type-specific requirements for cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.627

31 March 2020

Identifiers

10.1038/ONC.2010.627

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21258417%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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pubmed-PMC3109269

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21258417%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21258417%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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