(Q30519466)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Stress and aging induce distinct polyQ protein aggregation states (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

author name string

Lorenza E Moronetti Mazzeo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Devin Dersh

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Robert G Kalb

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Todd Lamitina

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

language of work or name

English

0 references

publication date

29 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

volume

109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

issue

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

10587-10592

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

Hypertonic stress induces rapid and widespread protein damage in C. elegans

2 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

The Caenorhabditis elegans mucin-like protein OSM-8 negatively regulates osmosensitive physiology via the transmembrane protein PTR-23

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Widespread protein aggregation as an inherent part of aging in C. elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Identification of a novel gene family involved in osmotic stress response in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Opposing activities protect against age-onset proteotoxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Huntington's disease: seeing the pathogenic process through a genetic lens

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Longevity and heat stress regulation in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Transduction of the stress signal and mechanisms of transcriptional regulation of heat shock/stress protein gene expression in higher eukaryotes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Living with water stress: evolution of osmolyte systems

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387092

Insulin signaling and the heat shock response modulate protein homeostasis in the Caenorhabditis elegans intestine during infection

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1108766109

Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1108766109

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1108766109

Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1108766109

Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22645345

12 December 2020

inferred from PubMed ID database lookup

Modeling polyglutamine pathogenesis in C. elegans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22645345

12 December 2020

inferred from PubMed ID database lookup

Polyglutamine protein aggregates are dynamic

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22645345

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1108766109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

22645345

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22645345%20AND%20SRC:MED&resulttype=core&format=json