(Q30159881)

8 June 2017

Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein (English)

1 reference

8 June 2017

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Zoya Ignatova

1

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author name string

Lila M Gierasch

series ordinal

2

1 reference

PubMed ID

16524881

8 June 2017

language of work or name

English

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publication date

8 March 2006

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Journal of Biological Chemistry

8 June 2017

9

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based on heuristic

inferred from page(s)

published in

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8 June 2017

281

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8 June 2017

18

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8 June 2017

12959-12967

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Glutamine repeats and neurodegeneration

8 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Protein aggregation and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Trinucleotide repeats: mechanisms and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Expansion explosion: new clues to the pathogenesis of repeat expansion neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Inefficient degradation of truncated polyglutamine proteins by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Polyglutamine is not all: the functional role of the AXH domain in the ataxin-1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Oligoproline effects on polyglutamine conformation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Intra- and intermolecular beta-pleated sheet formation in glutamine-repeat inserted myoglobin as a model for polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

The effects of aggregation-inducing motifs on amyloid formation of model proteins related to neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Dynamics of cellular retinoic acid binding protein I on multiple time scales with implications for ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Probing the folding pathway of a beta-clam protein with single-tryptophan constructs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Crystal structure of cellular retinoic acid binding protein I shows increased access to the binding cavity due to formation of an intermolecular beta-sheet

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Fluorescent labeling of recombinant proteins in living cells with FlAsH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Analysis of protein aggregation kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Mutational analysis of the structural organization of polyglutamine aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Nativelike secondary structure in interleukin-1 beta inclusion bodies by attenuated total reflectance FTIR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Crystal structure of a dimeric chymotrypsin inhibitor 2 mutant containing an inserted glutamine repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Solution structure of polyglutamine tracts in GST-polyglutamine fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Characterization of a possible amyloidogenic precursor in glutamine-repeat neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Polyglutamine fibrillogenesis: the pathway unfolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Characterizing the conformational ensemble of monomeric polyglutamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Allosteric switching by mutually exclusive folding of protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

Cavity formation before stable hydrogen bonding in the folding of a β-clam protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511523200

21 January 2018

Identifiers

DOI

10.1074/JBC.M511523200

1 reference

8 June 2017

1 reference

PubMed ID

16524881