(Q30531765)

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Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension

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Europe PubMed Central

PMC publication ID

12 October 2017

Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension (English)

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

arterial hypertension

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based on heuristic

inferred from title

pulmonary hypertension

1 reference

based on heuristic

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Jalees Rehman

14

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ORCID Public Data File 2021

author name string

Glenn Marsboom

1

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Europe PubMed Central

PMC publication ID

12 October 2017

Peter T Toth

2

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Europe PubMed Central

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12 October 2017

John J Ryan

3

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Europe PubMed Central

PMC publication ID

12 October 2017

Zhigang Hong

4

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Europe PubMed Central

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12 October 2017

Xichen Wu

5

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Europe PubMed Central

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12 October 2017

Yong-Hu Fang

6

1 reference

Europe PubMed Central

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12 October 2017

Thenappan Thenappan

7

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Europe PubMed Central

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12 October 2017

Lin Piao

8

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Europe PubMed Central

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12 October 2017

Hannah J Zhang

9

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Europe PubMed Central

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12 October 2017

Jennifer Pogoriler

10

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Europe PubMed Central

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12 October 2017

Yimei Chen

11

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Europe PubMed Central

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12 October 2017

Erik Morrow

12

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Europe PubMed Central

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12 October 2017

E Kenneth Weir

13

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Europe PubMed Central

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12 October 2017

Stephen L Archer

15

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Europe PubMed Central

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12 October 2017

publication date

17 April 2012

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Europe PubMed Central

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12 October 2017

Circulation Research

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Europe PubMed Central

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12 October 2017

110

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Europe PubMed Central

PMC publication ID

12 October 2017

11

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

1484-1497

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3539779/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Mitochondrial fusion and fission in cell life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.

1 reference

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Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions

1 reference

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20 June 2018

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury

1 reference

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20 June 2018

Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis

1 reference

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20 June 2018

Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells

1 reference

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20 June 2018

Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation.

1 reference

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20 June 2018

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

1 reference

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20 June 2018

Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization

1 reference

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20 June 2018

Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells

1 reference

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20 June 2018

Golgi ribbon unlinking: an organelle-based G2/M checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Mitochondrial dynamics in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Alterations of cellular bioenergetics in pulmonary artery endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

The anaphase promoting complex/cyclosome: a machine designed to destroy

1 reference

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20 June 2018

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

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20 June 2018

Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Disruption of fusion results in mitochondrial heterogeneity and dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts

1 reference

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20 June 2018

Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Fragmentation and dispersal of the pericentriolar Golgi complex is required for entry into mitosis in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

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Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1 reference

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20 June 2018

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

20 June 2018

Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

26 November 2018

Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

26 November 2018

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

26 November 2018

Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

26 November 2018

Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

26 November 2018

In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

26 November 2018

Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539779

26 November 2018

Cobalt-induced polycythaemia causing right ventricular hypertrophy and ascites in meat-type chickens

1 reference

https://pubmed.ncbi.nlm.nih.gov/22511751

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Voltage-gated K+ currents regulate resting membrane potential and [Ca2+]i in pulmonary arterial myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22511751

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit

1 reference

https://pubmed.ncbi.nlm.nih.gov/22511751

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuated K+ channel gene transcription in primary pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22511751

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCRESAHA.111.263848

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

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