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Transcriptional data: a new gateway to drug repositioning?
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scholarly article
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Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
title
Transcriptional data: a new gateway to drug repositioning?
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
main subject
drug repositioning
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based on heuristic
inferred from title
author
Timothy Rittman
object named as
Timothy Rittman
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2
0 references
Francesco Iorio
object named as
Francesco Iorio
series ordinal
1
0 references
Julio Saez-Rodriguez
object named as
Julio Saez-Rodriguez
series ordinal
5
0 references
author name string
Hong Ge
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
Michael Menden
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
publication date
7 August 2012
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Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
published in
Drug Discovery Today
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stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
volume
18
1 reference
stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
page(s)
350-357
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stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
issue
7-8
1 reference
stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
cites work
Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Drug discovery in the age of systems biology: the rise of computational approaches for data integration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Integrative genomics strategies to elucidate the complexity of drug response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
ProfileChaser: searching microarray repositories based on genome-wide patterns of differential expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Modulatory profiling identifies mechanisms of small molecule-induced cell death.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Discovery and preclinical validation of drug indications using compendia of public gene expression data
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
The emergence of genome-based drug repositioning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Literature mining, ontologies and information visualization for drug repurposing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Old friends in new guise: repositioning of known drugs with structural bioinformatics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
ArrayExpress update--an archive of microarray and high-throughput sequencing-based functional genomics experiments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Identification of small molecules enhancing autophagic function from drug network analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Drug-induced regulation of target expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Discovery of drug mode of action and drug repositioning from transcriptional responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Alzheimer's disease: clinical trials and drug development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
MARQ: an online tool to mine GEO for experiments with similar or opposite gene expression signatures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
A global map of human gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Indirect two-sided relative ranking: a robust similarity measure for gene expression data
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
How to improve R&D productivity: the pharmaceutical industry's grand challenge
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
GeneSigDB--a curated database of gene expression signatures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Predicting new molecular targets for known drugs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Disease signatures are robust across tissues and experiments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Human disease-drug network based on genomic expression profiles
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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Integrative analysis of the cancer transcriptome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
20 June 2018
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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Array of hope.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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Use of genome-wide association studies for drug repositioning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
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Causal reasoning on biological networks: interpreting transcriptional changes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
26 November 2018
Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
26 November 2018
Complementary new approaches enable repositioning of failed drug candidates.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
26 November 2018
Erectile-dysfunction therapies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
26 November 2018
Profiling Gene Expression Using Onto-Express
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625109
retrieved
26 November 2018
Signatures for drug repositioning
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22897878
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Prospects for productivity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22897878
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.DRUDIS.2012.07.014
1 reference
stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
PMCID
3625109
1 reference
stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
PubMed ID
22897878
1 reference
stated in
Europe PubMed Central
PMCID
3625109
retrieved
14 September 2017
ResearchGate publication ID
230634246
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