(Q30566020)

20 August 2017

Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death (English)

1 reference

20 August 2017

1 reference

1 reference

Lishu Duan

1

1 reference

20 August 2017

Bula J Bhattacharyya

2

1 reference

20 August 2017

Abdelhak Belmadani

3

1 reference

20 August 2017

Liuliu Pan

4

1 reference

20 August 2017

Richard J Miller

5

1 reference

20 August 2017

John A Kessler

6

1 reference

20 August 2017

8 January 2014

1 reference

Molecular Neurodegeneration

20 August 2017

1 reference

20 August 2017

9

1 reference

20 August 2017

3

1 reference

https://scigraph.springernature.com/pub.10.1186/1750-1326-9-3

20 August 2017

0 references

cites work

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Modeling familial Alzheimer's disease with induced pluripotent stem cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Genome-wide association studies in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

The role of apolipoprotein E in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Induced pluripotent stem cell lines derived from human somatic cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Neuronal and glial calcium signaling in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

The relationship between amyloid and tau.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Molecular mechanisms of calcium-dependent excitotoxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Specific regional transcription of apolipoprotein E in human brain neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Apolipoprotein E alleles as risk factors in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Amyloid beta-protein, APOE genotype and head injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Excitatory amino acids as a final common pathway for neurologic disorders.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Observations on the brains of demented old people

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Amyloid plaque core protein in Alzheimer disease and Down syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

20 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Differentiation of mouse embryonic stem cells into a defined neuronal lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-3

Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans?

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's disease.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896712

No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo

26 November 2018

1 reference

12 December 2020

Ontogeny of cholinergic neurons in the mouse forebrain

1 reference

12 December 2020

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1 reference

12 December 2020

Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide

1 reference

12 December 2020

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

12 December 2020

Identifiers

DOI

10.1186/1750-1326-9-3

1 reference

Dimensions Publication ID

20 August 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1750-1326-9-3

1 reference

20 August 2017

PubMed publication ID

24401693

1 reference