(Q39968931)

16 September 2017

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression (English)

1 reference

16 September 2017

Catherine R Burton

1

1 reference

16 September 2017

Jere E Meredith

2

1 reference

16 September 2017

Donna M Barten

3

1 reference

16 September 2017

Margi E Goldstein

4

1 reference

16 September 2017

Carol M Krause

5

1 reference

16 September 2017

Cathy J Kieras

6

1 reference

16 September 2017

Lisa Sisk

7

1 reference

16 September 2017

Lawrence G Iben

8

1 reference

16 September 2017

Craig Polson

9

1 reference

16 September 2017

Mark W Thompson

10

1 reference

16 September 2017

Xu-Alan Lin

11

1 reference

16 September 2017

Jason Corsa

12

1 reference

16 September 2017

Tracey Fiedler

13

1 reference

16 September 2017

Maria Pierdomenico

14

1 reference

16 September 2017

Yang Cao

15

1 reference

16 September 2017

Arthur H Roach

16

1 reference

16 September 2017

Joseph L Cantone

17

1 reference

16 September 2017

Michael J Ford

18

1 reference

16 September 2017

Dieter M Drexler

19

1 reference

16 September 2017

Richard E Olson

20

1 reference

16 September 2017

Michael G Yang

21

1 reference

16 September 2017

Carl P Bergstrom

22

1 reference

16 September 2017

Kate E McElhone

23

1 reference

16 September 2017

Joanne J Bronson

24

1 reference

16 September 2017

John E Macor

25

1 reference

16 September 2017

Yuval Blat

26

1 reference

16 September 2017

Robert H Grafstrom

27

1 reference

16 September 2017

Andrew M Stern

28

1 reference

16 September 2017

Dietmar A Seiffert

29

1 reference

16 September 2017

Robert Zaczek

30

1 reference

16 September 2017

Charles F Albright

31

1 reference

16 September 2017

Jeremy H Toyn

32

1 reference

16 September 2017

language of work or name

English

0 references

publication date

23 June 2008

1 reference

Journal of Biological Chemistry

16 September 2017

1 reference

16 September 2017

283

1 reference

16 September 2017

34

1 reference

16 September 2017

22992-23003

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

16 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Adhesive force of a single gecko foot-hair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Al

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

The same gamma-secretase accounts for the multiple intramembrane cleavages of APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804175200

21 January 2018

Identifiers

DOI

10.1074/JBC.M804175200

1 reference

release_nsjei2prsrbuvoomulrh6jkckq

16 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nsjei2prsrbuvoomulrh6jkckq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference