(Q30586379)

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Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H⁺ extrusion, cell migration and survival.

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13 March 2020

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H⁺ extrusion, cell migration and survival (English)

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13 March 2020

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7

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13 March 2020

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13 March 2020

8

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13 March 2020

author name string

Damin Cong

1

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13 March 2020

Wen Zhu

2

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13 March 2020

Kelli B Pointer

4

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13 March 2020

Paul A Clark

5

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13 March 2020

Hongmei Shen

6

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13 March 2020

Dandan Sun

9

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13 March 2020

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9 April 2014

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13 March 2020

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13 March 2020

35

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13 March 2020

9

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13 March 2020

2014-2024

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13 March 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4146414/fullTextXML

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The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2.

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B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger

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The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells

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The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24717311

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/CARCIN/BGU089

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24717311%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

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13 March 2020

1 reference

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13 March 2020

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