(Q30614255)

15 October 2017

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo (English)

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15 October 2017

8

J Keith Joung

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15 October 2017

John A Zuris

1

1 reference

15 October 2017

David B Thompson

2

1 reference

15 October 2017

Yilai Shu

3

1 reference

15 October 2017

John P Guilinger

4

1 reference

15 October 2017

Jeffrey L Bessen

5

1 reference

15 October 2017

Johnny H Hu

6

1 reference

15 October 2017

Morgan L Maeder

7

1 reference

15 October 2017

Zheng-Yi Chen

9

1 reference

15 October 2017

David R Liu

10

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15 October 2017

30 October 2014

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15 October 2017

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15 October 2017

33

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15 October 2017

73-80

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15 October 2017

1

1 reference

describes a project that uses

15 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4289409/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Endosomal escape: a bottleneck in intracellular delivery

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

CRISPR-Cas systems for editing, regulating and targeting genomes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Latent cytokines for targeted therapy of inflammatory disorders.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

CRISPR RNA-guided activation of endogenous human genes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Robust, synergistic regulation of human gene expression using TALE activators

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

RNA-guided human genome engineering via Cas9

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Liposomal drug delivery systems: from concept to clinical applications

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

NIH Image to ImageJ: 25 years of image analysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Cellular uptake mechanisms and endosomal trafficking of supercharged proteins.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Engineering and identifying supercharged proteins for macromolecule delivery into mammalian cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Genome editing with engineered zinc finger nucleases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

A rapid and general assay for monitoring endogenous gene modification

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Electroporation for the delivery of DNA-based vaccines and immunotherapeutics: current clinical developments

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Protein therapeutics: a summary and pharmacological classification

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Supercharging proteins can impart unusual resilience

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Math1-driven GFP expression in the developing nervous system of transgenic mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Protein encapsulation in liposomes: efficiency depends on interactions between protein and phospholipid bilayer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Improving protein therapeutics with sustained-release formulations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289409

Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene

14 July 2018

1 reference

Elucidation of Piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation

21 January 2018

1 reference

Safety and efficacy of RNAi therapy for transthyretin amyloidosis.

21 January 2018

1 reference

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo.

21 January 2018

1 reference

Intracellular delivery of proteins with a new lipid-mediated delivery system

21 January 2018

1 reference

A peptide carrier for the delivery of biologically active proteins into mammalian cells.

21 January 2018

1 reference

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

21 January 2018

1 reference

Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein

21 January 2018

1 reference

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25357182

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intrinsically cell-permeable miniature proteins based on a minimal cationic PPII motif

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25357182

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NBT.3081

1 reference

15 October 2017

1 reference

15 October 2017

1 reference