(Q30623992)

19 October 2017

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL (English)

1 reference

19 October 2017

1 reference

1 reference

5

1 reference

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3 June 2020

Kate E. Lawlor

1

1 reference

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3 June 2020

Motti Gerlic

4

1 reference

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3 June 2020

Akshay A D'Cruz

6

1 reference

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3 June 2020

Holly Anderton

9

1 reference

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3 June 2020

Seth L Masters

10

1 reference

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3 June 2020

Maryam Rashidi

11

1 reference

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3 June 2020

W. Wei-Lynn Wong

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693118%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

John Silke

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693118%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

David L Vaux

19

1 reference

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3 June 2020

author name string

Nufail Khan

2

1 reference

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3 June 2020

Alison Mildenhall

3

1 reference

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3 June 2020

Cathrine Hall

7

1 reference

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3 June 2020

Sukhdeep Kaur Spall

8

1 reference

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3 June 2020

Ian P Wicks

12

1 reference

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3 June 2020

Warren S Alexander

13

1 reference

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3 June 2020

Yasuhiro Mitsuuchi

14

1 reference

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3 June 2020

Christopher A Benetatos

15

1 reference

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3 June 2020

Stephen M Condon

16

1 reference

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3 June 2020

James E Vince

20

1 reference

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3 June 2020

language of work or name

English

0 references

publication date

18 February 2015

1 reference

19 October 2017

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693118%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

6

1 reference

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3 June 2020

page(s)

6282

1 reference

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Creative Commons Attribution 4.0 International

3 June 2020

copyright license

start time

18 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

RIP3 induces apoptosis independent of pronecrotic kinase activity

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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

20 June 2018

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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

20 June 2018

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XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation

20 June 2018

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MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

20 June 2018

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Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

20 June 2018

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

20 June 2018

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Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

20 June 2018

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Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

20 June 2018

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More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

20 June 2018

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FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

20 June 2018

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

20 June 2018

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

20 June 2018

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Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

20 June 2018

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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

20 June 2018

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Inflammatory pathways in spondyloarthritis

20 June 2018

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RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

20 June 2018

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Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

20 June 2018

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TRPM2 links oxidative stress to NLRP3 inflammasome activation

20 June 2018

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Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation

20 June 2018

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TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

20 June 2018

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20 June 2018

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Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

20 June 2018

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The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.

20 June 2018

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Critical role for calcium mobilization in activation of the NLRP3 inflammasome

20 June 2018

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cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.

20 June 2018

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Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice

20 June 2018

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Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

20 June 2018

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IAPs limit activation of RIP kinases by TNF receptor 1 during development

20 June 2018

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

20 June 2018

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Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

20 June 2018

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20 June 2018

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The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

20 June 2018

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

20 June 2018

1 reference

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

20 June 2018

1 reference

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Innate immunity and rheumatoid arthritis

20 June 2018

1 reference

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Mechanisms of disease: a 'DAMP' view of inflammatory arthritis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Caspase-8 serves both apoptotic and nonapoptotic roles

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Critical role for granulocyte colony-stimulating factor in inflammatory arthritis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

The K/BxN mouse: a model of human inflammatory arthritis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346630

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

20 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7282

Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7282

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7282

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7282

Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis

21 January 2018

1 reference

12 December 2020

Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

1 reference

12 December 2020

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

1 reference

12 December 2020

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS7282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693118%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

ADS bibcode

2015NatCo...6.6282L

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693118%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693118%20AND%20SRC:MED&resulttype=core&format=json