(Q34409204)

25288762

2 August 2017

title

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death (English)

1 reference

2 August 2017

1 reference

9

1 reference

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5 June 2020

Jeffrey J Babon

12

1 reference

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5 June 2020

Martin J. Scanlon

14

1 reference

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5 June 2020

James Murphy

19

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5 June 2020

John Silke

20

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5 June 2020

author name string

Joanne M Hildebrand

1

1 reference

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5 June 2020

Maria C Tanzer

2

1 reference

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5 June 2020

Isabelle S Lucet

3

1 reference

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5 June 2020

Samuel N Young

4

1 reference

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5 June 2020

Sukhdeep K Spall

5

1 reference

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5 June 2020

Pooja Sharma

6

1 reference

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5 June 2020

Catia Pierotti

7

1 reference

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5 June 2020

Jean-Marc Garnier

8

1 reference

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5 June 2020

Andrew I Webb

10

1 reference

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5 June 2020

Anne Tripaydonis

11

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5 June 2020

Mark D Mulcair

13

1 reference

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5 June 2020

Warren S Alexander

15

1 reference

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5 June 2020

Andrew F Wilks

16

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5 June 2020

Peter E Czabotar

17

1 reference

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5 June 2020

Guillaume Lessene

18

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5 June 2020

language of work or name

English

0 references

publication date

6 October 2014

1 reference

25288762

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

1 reference

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5 June 2020

volume

111

1 reference

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5 June 2020

issue

42

1 reference

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5 June 2020

page(s)

15072-15077

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288762%20AND%20SRC:MED&resulttype=core&format=json

RIPK1- and RIPK3-induced cell death mode is determined by target availability

5 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Necroptosis induced by RIPK3 requires MLKL but not Drp1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Techniques to examine nucleotide binding by pseudokinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210347

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1408987111

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1408987111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1408987111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288762%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288762%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

25288762

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288762%20AND%20SRC:MED&resulttype=core&format=json