(Q30629611)

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Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 June 2017

Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

Human Induced Pluripotent Stem Cells

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based on heuristic

inferred from title

electrophysiology

1 reference

based on heuristic

inferred from title

author name string

Kate Harris

1

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

Mike Aylott

2

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

Yi Cui

3

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

James B Louttit

4

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

Nicholas C McMahon

5

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

Arun Sridhar

6

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

publication date

20 May 2013

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

Toxicological Sciences

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Europe PubMed Central

PubMed publication ID

25 June 2017

134

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Europe PubMed Central

PubMed publication ID

25 June 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

412-426

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

QT PRODACT: in vivo QT assay with a conscious monkey for assessment of the potential for drug-induced QT interval prolongation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

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Opportunities for use of human iPS cells in predictive toxicology

1 reference

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A method for QT correction based on beat-to-beat analysis of the QT/RR interval relationship in conscious telemetred beagle dogs

1 reference

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Differential effects on action potential duration of class IA, B and C antiarrhythmic drugs: modulation by stimulation rate and extracellular K+ concentration.

1 reference

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21 January 2018

How do the top 12 pharmaceutical companies operate safety pharmacology?

1 reference

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Cellular and ionic basis for the sex-related difference in the manifestation of the Brugada syndrome and progressive conduction disease phenotypes

1 reference

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21 January 2018

Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

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The electrophysiological effects of cardiac glycosides in human iPSC-derived cardiomyocytes and in guinea pig isolated hearts

1 reference

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21 January 2018

Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures.

1 reference

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ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

1 reference

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21 January 2018

On the relationship between block of the cardiac Na⁺ channel and drug-induced prolongation of the QRS complex

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Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical

1 reference

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21 January 2018

Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

On the road to iPS cell cardiovascular applications.

1 reference

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21 January 2018

Can the pharmaceutical industry reduce attrition rates?

1 reference

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Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models

1 reference

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21 January 2018

A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

1 reference

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21 January 2018

Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation

1 reference

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21 January 2018

Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

Lack of action potential-prolonging effect of terfenadine on rabbit myocardial tissue preparations

1 reference

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21 January 2018

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

QT PRODACT: sensitivity and specificity of the canine telemetry assay for detecting drug-induced QT interval prolongation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

The determination and interpretation of the therapeutic index in drug development

1 reference

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21 January 2018

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells

1 reference

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21 January 2018

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

Propofol block of cardiac sodium currents in rat isolated myocardial cells is increased at depolarized resting potentials.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

QT PRODACT: in vivo QT assay in anesthetized dog for detecting the potential for QT interval prolongation by human pharmaceuticals

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

A framework to assess the translation of safety pharmacology data to humans.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT113

21 January 2018

Safety and secondary pharmacology: successes, threats, challenges and opportunities

1 reference

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21 January 2018

The application of in vitro methods to safety pharmacology

1 reference

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21 January 2018

Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic

1 reference

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21 January 2018

Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?

1 reference

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21 January 2018

Identifiers

10.1093/TOXSCI/KFT113

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

ResearchGate publication ID

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