(Q37202248)

18 August 2017

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title

Safety and secondary pharmacology: successes, threats, challenges and opportunities (English)

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18 August 2017

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Jean-Pierre Valentin

1

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18 August 2017

Tim Hammond

series ordinal

2

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18 August 2017

publication date

3 June 2008

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Journal of Pharmacological and Toxicological Methods

18 August 2017

published in

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18 August 2017

volume

58

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18 August 2017

issue

2

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18 August 2017

page(s)

77-87

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QT PRODACT: in vivo QT assay with a conscious monkey for assessment of the potential for drug-induced QT interval prolongation

18 August 2017

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What is the future role of pharmacologists in the pharmaceutical industry?

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Sudden death of a volunteer

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Use and application of stem cells in toxicology

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Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death

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Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability

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In silico prediction of drug safety: despite progress there is abundant room for improvement

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QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization

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7 January 2021

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Can the pharmaceutical industry reduce attrition rates?

7 January 2021

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Timing of new black box warnings and withdrawals for prescription medications

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Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs.

7 January 2021

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Concordance of the toxicity of pharmaceuticals in humans and in animals

7 January 2021

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QT PRODACT: comparison of non-clinical studies for drug-induced delay in ventricular repolarization and their role in safety evaluation in humans

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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QT PRODACT: inter-facility variability in electrocardiographic and hemodynamic parameters in conscious dogs and monkeys

7 January 2021

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Adverse events in phase-I studies: a report in 1015 healthy volunteers

7 January 2021

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"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics

7 January 2021

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A model for human ventricular tissue

7 January 2021

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Challenges facing pharmacology--the in vivo situation

7 January 2021

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Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs

7 January 2021

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Clinically significant adverse effects in a Phase 1 testing program

7 January 2021

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In vivo drug discovery in the zebrafish

7 January 2021

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10.1016/J.VASCN.2008.05.007

7 January 2021

Identifiers

DOI

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18 August 2017

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