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Beta-secretase (BACE) as a drug target for Alzheimer's disease
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
review article
1 reference
stated in
Europe PubMed Central
title
Beta-secretase (BACE) as a drug target for Alzheimer's disease
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
main subject
Alzheimer's disease
1 reference
based on heuristic
inferred from title
author name string
Robert Vassar
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
language of work or name
English
0 references
publication date
1 December 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
published in
Advanced Drug Delivery Reviews
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
volume
54
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
issue
12
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
page(s)
1589-1602
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
cites work
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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Genetics of Alzheimer's disease
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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The role of A beta 42 in Alzheimer's disease
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Function and dysfunction of the presenilins
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Alzheimer's disease: genes, proteins, and therapy
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Abeta-generating enzymes: recent advances in beta- and gamma-secretase research
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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inferred from DOI database lookup
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Purification and cloning of amyloid precursor protein beta-secretase from human brain
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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inferred from DOI database lookup
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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inferred from DOI database lookup
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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inferred from DOI database lookup
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Amyloid beta-peptide is produced by cultured cells during normal metabolism
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Generation of amyloid beta protein from its precursor is sequence specific
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Expression analysis of BACE2 in brain and peripheral tissues
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
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The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
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inferred from DOI database lookup
Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
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inferred from DOI database lookup
The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association studies using novel polymorphisms in BACE1 and BACE2.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BACE2 functions as an alternative alpha-secretase in cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Maturation and pro-peptide cleavage of beta-secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Processing of beta-secretase by furin and other members of the proprotein convertase family
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Prodomain processing of Asp1 (BACE2) is autocatalytic.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
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Phosphorylation regulates intracellular trafficking of beta-secretase
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
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Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0169-409X(02)00157-6
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
PubMed ID
12453676
1 reference
stated in
Europe PubMed Central
PubMed ID
12453676
retrieved
26 June 2017
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