(Q30799661)

26 June 2017

1 reference

title

The ATPases: a new family for a family-based drug design approach (English)

1 reference

26 June 2017

Patrick Chène

1

1 reference

PubMed ID

12783580

26 June 2017

language of work or name

English

0 references

publication date

1 June 2003

1 reference

Expert Opinion on Therapeutic Targets

26 June 2017

1 reference

26 June 2017

7

1 reference

26 June 2017

453-461

1 reference

26 June 2017

3

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

26 June 2017

1 reference

Structural biology in drug design: selective protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The human ATP-binding cassette (ABC) transporter superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

A functional-phylogenetic classification system for transmembrane solute transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Structure and association of ATP-binding cassette transporter nucleotide-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Mechanism of ABC transporters: a molecular dynamics simulation of a well characterized nucleotide-binding subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The catalytic cycle of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Mammalian ABC transporters in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The human ATP-binding cassette transporter genes: from the bench to the bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

P-glycoprotein as a drug target in the treatment of multidrug resistant cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Evolution of substrate specificities in the P-type ATPase superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The cell biology of ion pumps: sorting and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Structural organization, ion transport, and energy transduction of P-type ATPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

A calcium pump made visible

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Structural changes in the calcium pump accompanying the dissociation of calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Structure and function of the P-type ATPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Myocardial Na,K-ATPase: the molecular basis for the hemodynamic effect of digoxin therapy in congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The proton-pump inhibitors: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The vacuolar (H+)-ATPases--nature's most versatile proton pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Selective inhibition of osteoclast vacuolar H(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Vacuolar H(+)-ATPase: functional mechanisms and potential as a target for cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

All kinesin superfamily protein, KIF, genes in mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Kinesin carries the signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Kinesin and dynein superfamily proteins in organelle transport and cell division.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Three-dimensional structure of motor molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The design plan of kinesin motors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Microtubule interaction site of the kinesin motor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The role of ATP hydrolysis for kinesin processivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Switch-based mechanism of kinesin motors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

A structural change in the kinesin motor protein that drives motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Past and future of the mitotic spindle as an oncology target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

A marine natural product inhibitor of kinesin motors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Unwinding the 'Gordian knot' of helicase action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Helicase structure and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

DExD/H box RNA helicases: from generic motors to specific dissociation functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

A new twist on RNA helicases: DExH/D box proteins as RNPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Helicase motifs: the engine that powers DNA unwinding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

A general model for nucleic acid helicases and their "coupling" within macromolecular machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

DNA helicases: 'inching forward'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Antihelicase action of CI-958, a new drug for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Cells in stress: transcriptional activation of heat shock genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Protein folding in vivo: the importance of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Unfolding the role of chaperones and chaperonins in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The Hsp70 and Hsp60 chaperone machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Structure and in vivo function of Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Identification of a major subfamily of large hsp70-like proteins through the cloning of the mammalian 110-kDa heat shock protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Heat shock proteins: endogenous modulators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Heat-shock proteins as death determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Stress management - heat shock protein-70 and the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Stereospecific antitumor activity of radicicol oxime derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The AAA team: related ATPases with diverse functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

AAA+ proteins and substrate recognition, it all depends on their partner in crime

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Microtubule disassembly by ATP-dependent oligomerization of the AAA enzyme katanin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

GHKL, an emergent ATPase/kinase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

An atypical topoisomerase II from Archaea with implications for meiotic recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

The P-loop--a common motif in ATP- and GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Nucleoside triphosphate-binding proteins: different scaffolds to achieve phosphoryl transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

Sequence and structure classification of kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.453

21 January 2018

Identifiers

DOI

10.1517/14728222.7.3.453

1 reference

26 June 2017

1 reference

PubMed ID

12783580