(Q30831001)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

review article

1 reference

title

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

Klas G Wiman

series ordinal

1

1 reference

26 June 2017

publication date

1 January 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

Advances in Cancer Research

28 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

volume

97

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

page(s)

321-338

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

28 December 2019

cites work

1 reference

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7 January 2021

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

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7 January 2021

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

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7 January 2021

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

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7 January 2021

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

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7 January 2021

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

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7 January 2021

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

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7 January 2021

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

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7 January 2021

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

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7 January 2021

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

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7 January 2021

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

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7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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7 January 2021

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma

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7 January 2021

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

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7 January 2021

p53 functions as a cell cycle control protein in osteosarcomas

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7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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7 January 2021

Definition of a consensus binding site for p53

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7 January 2021

WAF1, a potential mediator of p53 tumor suppression

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7 January 2021

The p53 proto-oncogene can act as a suppressor of transformation

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7 January 2021

Pharmacological rescue of mutant p53 conformation and function

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7 January 2021

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia

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7 January 2021

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

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7 January 2021

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Allosteric activation of latent p53 tetramers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Regulation of the specific DNA binding function of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Cancer. p53, guardian of the genome

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Rearrangement of the p53 gene in human osteogenic sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

1 reference

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7 January 2021

Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.

1 reference

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7 January 2021

Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Mutations in the p53 gene occur in diverse human tumour types

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.

1 reference

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7 January 2021

Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Structure-based rescue of common tumor-derived p53 mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Strategies for therapeutic targeting of the p53 pathway in cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Inactivation of p53 Gene Expression by an Insertion of Moloney Murine Leukemia Virus-Like DNA Sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

The retinoblastoma gene: role in cell cycle control and cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6

7 January 2021

10.1016/S0065-230X(06)97014-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference