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Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.
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1 reference
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Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
review article
1 reference
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Europe PubMed Central
title
Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
author
Klas Wiman
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
author name string
Klas G Wiman
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
retrieved
26 June 2017
publication date
1 January 2007
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
published in
Advances in Cancer Research
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
volume
97
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
page(s)
321-338
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
cites work
p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 functions as a cell cycle control protein in osteosarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Definition of a consensus binding site for p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
WAF1, a potential mediator of p53 tumor suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 proto-oncogene can act as a suppressor of transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological rescue of mutant p53 conformation and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent cell death/apoptosis is required for a productive adenovirus infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allosteric activation of latent p53 tetramers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the specific DNA binding function of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small peptides activate the latent sequence-specific DNA binding function of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer. p53, guardian of the genome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T antigen is bound to a host protein in SY40-transformed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rearrangement of the p53 gene in human osteogenic sarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the p53 gene occur in diverse human tumour types
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based rescue of common tumor-derived p53 mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of human papillomavirus types 16 and 18 E6 proteins with p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strategies for therapeutic targeting of the p53 pathway in cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of p53 Gene Expression by an Insertion of Moloney Murine Leukemia Virus-Like DNA Sequences
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The retinoblastoma gene: role in cell cycle control and cell differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997014-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0065-230X(06)97014-6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
PubMed publication ID
17419952
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17419952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 December 2019
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