(Q30891417)

20 August 2017

In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes (English)

1 reference

20 August 2017

Leonid Gaidukov

1

1 reference

20 August 2017

Dganit Bar

2

1 reference

20 August 2017

Shiri Yacobson

3

1 reference

20 August 2017

Esmira Naftali

4

1 reference

20 August 2017

Olga Kaufman

5

1 reference

20 August 2017

Rinat Tabakman

6

1 reference

20 August 2017

Dan S Tawfik

7

1 reference

20 August 2017

Etgar Levy-Nissenbaum

8

1 reference

20 August 2017

17 November 2009

1 reference

BMC Clinical Pharmacology

20 August 2017

1 reference

20 August 2017

9

1 reference

20 August 2017

18

1 reference

https://scigraph.springernature.com/pub.10.1186/1472-6904-9-18

20 August 2017

0 references

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The paraoxonases: role in human diseases and methodological difficulties in measurement.

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Directed enzyme evolution via small and effective neutral drift libraries

21 June 2018

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Molecular engineering and design of therapeutic antibodies

21 June 2018

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Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk

21 June 2018

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Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins

21 June 2018

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S-Glutathionylation regulates HDL-associated paraoxonase 1 (PON1) activity

21 June 2018

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Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis

21 June 2018

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Pathways for oxidation of high-density lipoprotein in human cardiovascular disease.

21 June 2018

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Recombinant apolipoprotein A-IMilano for the treatment of cardiovascular diseases.

21 June 2018

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The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Apolipoprotein A-I mimetic peptides

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Myeloperoxidase and cardiovascular disease.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Directed evolution of proteins for heterologous expression and stability.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

The paraoxonase gene family and atherosclerosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

The 'evolvability' of promiscuous protein functions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Paraoxonase 1 activity, concentration and genotype in cardiovascular disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Protection against the lethal effects of organophosphates by pyridine-2-aldoxime methiodide

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

The enzyme as drug: application of enzymes as pharmaceuticals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

PON1 paraoxonase activity is reduced during HDL oxidation and is an indicator of HDL antioxidant capacity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Serum paraoxonase is reduced in type 1 diabetic patients compared to non-diabetic, first degree relatives; influence on the ability of HDL to protect LDL from oxidation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Glycation impairs high-density lipoprotein function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

High density lipoprotein oxidation: in vitro susceptibility and potential in vivo consequences

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Human serum Paraoxonase/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Differential distribution of free and bound glutathione and cyst(e)ine in human blood

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Thiol/disulfide exchange equilibria and disulfide bond stability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Paraoxonase protects against chlorpyrifos toxicity in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Binding of high density lipoprotein to cultured fibroblasts after chemical alteration of apoprotein amino acid residues

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

12 Stability constants for biologically important metal-ligand complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds.

21 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Effect of glycation of high density lipoproteins on their physicochemical properties and on paraoxonase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

HDL subfraction distribution of paraoxonase-1 and its relevance to enzyme activity and resistance to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Small, dense lipoprotein particles and reduced paraoxonase-1 in patients with the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Serum albumin is as efficient as paraxonase in the detoxication of paraoxon at toxicologically relevant concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Stability of highly purified human paraoxonase (PON1): association with human phosphate binding protein (HPBP) is essential for preserving its active conformation(s).

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Optimized bacterial expression of human apolipoprotein A-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Enhanced protein glutathiolation and oxidative stress in cigarette smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-9-18

Reagent or myeloperoxidase-generated hypochlorite affects discrete regions in lipid-free and lipid-associated human apolipoprotein A-I.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785756

Comparison of purified human and rabbit serum paraoxonases

25 November 2018

1 reference

12 December 2020

Effects of Reagent and Enzymatically Generated Hypochlorite on Physicochemical and Metabolic Properties of High Density Lipoproteins

1 reference

12 December 2020

Calcium binding by human and rabbit serum paraoxonases. Structural stability and enzymatic activity

1 reference

12 December 2020

Enzymes hydrolyzing organophosphates as potential catalytic scavengers against organophosphate poisoning

1 reference

12 December 2020

The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux

1 reference

12 December 2020

Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters

1 reference

12 December 2020

Enzymatically Active Paraoxonase-1 Is Located at the External Membrane of Producing Cells and Released by a High Affinity, Saturable, Desorption Mechanism

1 reference

12 December 2020

Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1)

1 reference

12 December 2020

Characterization of discoidal complexes of phosphatidylcholine, apolipoprotein A-I and cholesterol by gradient gel electrophoresis

1 reference

12 December 2020

Identifiers

DOI

10.1186/1472-6904-9-18

1 reference

Dimensions Publication ID

20 August 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1472-6904-9-18

1 reference

20 August 2017

1 reference