(Q30911799)

27 June 2017

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title

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein (English)

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27 June 2017

Steven Fletcher

1

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27 June 2017

Joel A Drewry

2

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27 June 2017

Vijay M Shahani

3

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27 June 2017

Brent D G Page

4

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27 June 2017

Patrick T Gunning

5

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27 June 2017

1 December 2009

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Biochemistry and Cell Biology

27 June 2017

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27 June 2017

87

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27 June 2017

6

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27 June 2017

825-833

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Three-dimensional structure of the Stat3beta homodimer bound to DNA

27 June 2017

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Design, synthesis, and studies of small molecule STAT3 inhibitors

21 January 2018

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21 January 2018

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Stat proteins and oncogenesis

21 January 2018

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Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor

21 January 2018

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Protein surface recognition and proteomimetics: mimics of protein surface structure and function

21 January 2018

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Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

21 January 2018

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Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains

21 January 2018

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Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders

21 January 2018

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Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening

21 January 2018

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Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

21 January 2018

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Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

21 January 2018

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Cyclization strategies in peptide derived drug design

21 January 2018

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Resveratrol analog, 3,4,5,4'-tetrahydroxystilbene, differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts

21 January 2018

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Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol

21 January 2018

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Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus

21 January 2018

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Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics

21 January 2018

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Structural basis for the binding of high affinity phosphopeptides to Stat3.

21 January 2018

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Discovery of chromone-based inhibitors of the transcription factor STAT5.

21 January 2018

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Identification of a high-affinity phosphopeptide inhibitor of Stat3.

21 January 2018

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Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells

21 January 2018

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A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3.

21 January 2018

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Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

21 January 2018

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JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells.

21 January 2018

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

21 January 2018

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A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D.

21 January 2018

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Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 January 2018

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A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

21 January 2018

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Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters

21 January 2018

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Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

21 January 2018

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PTP1B as a drug target: recent developments in PTP1B inhibitor discovery

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O09-044

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27 June 2017

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