(Q30940461)

27 June 2017

title

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data? (English)

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27 June 2017

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3

Zhengyin Yan

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27 June 2017

1

Gary W Caldwell

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27 June 2017

2

John A Masucci

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27 June 2017

4

William Hageman

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27 June 2017

publication date

1 April 2004

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European Journal of Drug Metabolism and Pharmacokinetics

27 June 2017

published in

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27 June 2017

volume

29

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27 June 2017

issue

2

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27 June 2017

page(s)

133-143

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Interspecies scaling: predicting volumes, mean residence time and elimination half-life. Some suggestions.

27 June 2017

cites work

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https://api.crossref.org/works/10.1007%2FBF03190588

21 January 2018

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Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

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Pharmacokinetics and interspecies scaling of a novel VEGF receptor inhibitor, SU5416.

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Allometric scaling of xenobiotic clearance: uncertainty versus universality

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Compound optimization in early- and late-phase drug discovery: acceptable pharmacokinetic properties utilizing combined physicochemical, in vitro and in vivo screens

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High throughput liquid chromatography-mass spectrometry assessment of the metabolic activity of commercially available hepatocytes from 96-well plates.

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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

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Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

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Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?

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Interspecies scaling of renally secreted drugs

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12 December 2020

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Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

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Allometric issues in drug development

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12 December 2020

Interspecies scaling: a comparative study for the prediction of clearance and volume using two or more than two species

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In vitro-in vivo correlation of the pharmacokinetics of vinpocetine

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12 December 2020

Allometric pharmacokinetic scaling: towards the prediction of human oral pharmacokinetics

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12 December 2020

The absolute oral bioavailability of selected drugs.

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Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans.

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12 December 2020

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12 December 2020

Can absolute oral bioavailability in humans be predicted from animals? A comparison of allometry and different indirect methods

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Scaling basic toxicokinetic parameters from rat to man.

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Predicting drug pharmacokinetics in humans from in vitro metabolism studies

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Correlation of plasma clearance of 54 extensively metabolized drugs between humans and rats: mean allometric coefficient of 0.66.

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The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery

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Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data

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12 December 2020

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

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12 December 2020

Drug metabolism and pharmacokinetics in drug discovery.

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12 December 2020

Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics

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Prediction of human clearance from animal data and molecular structural parameters using multivariate regression analysis

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Novel procedure for rapid pharmacokinetic screening of discovery compounds in rats

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12 December 2020

Drug selection in early drug development: screening for acceptable pharmacokinetic properties using combined in vitro and computational approaches

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Physiologically based pharmacokinetic model for terbinafine in rats and humans

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12 December 2020

The prediction of human clearance from hepatic microsomal metabolism data

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12 December 2020

Prediction of clearance, volume of distribution and half-life by allometric scaling and by use of plasma concentrations predicted from pharmacokinetic constants: a comparative study

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12 December 2020

First time in human for GV196771: interspecies scaling applied on dose selection.

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12 December 2020

Interspecies extrapolation of pharmacokinetics

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12 December 2020

Preclinical drug metabolism in the age of high-throughput screening: an industrial perspective

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12 December 2020

Identifiers

DOI

10.1007/BF03190588

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Dimensions Publication ID

27 June 2017

1030354279

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