(Q30997889)

3 November 2017

Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation (English)

1 reference

3 November 2017

0 references

Tyler N Graf

3

0 references

Nicholas H. Oberlies

object named as

Nicholas H Oberlies

4

0 references

author name string

Jessica Wagoner

1

1 reference

3 November 2017

Chihiro Morishima

2

1 reference

3 November 2017

Elodie Teissier

5

1 reference

3 November 2017

Eve-Isabelle Pécheur

6

1 reference

3 November 2017

John E Tavis

7

1 reference

3 November 2017

Stephen J Polyak

8

1 reference

3 November 2017

language of work or name

English

0 references

publication date

28 January 2011

1 reference

3 November 2017

1 reference

3 November 2017

6

1 reference

3 November 2017

1

1 reference

3 November 2017

e16464

1 reference

Creative Commons Attribution 4.0 International

3 November 2017

start time

28 January 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Multiple effects of silymarin on the hepatitis C virus lifecycle

21 June 2018

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Identification of hepatoprotective flavonolignans from silymarin

21 June 2018

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Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats

21 June 2018

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Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase

21 June 2018

1 reference

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Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations

21 June 2018

1 reference

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Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma

21 June 2018

1 reference

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Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C

21 June 2018

1 reference

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Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection

21 June 2018

1 reference

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Drug-drug interactions of silymarin on the perspective of pharmacokinetics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Early steps of the hepatitis C virus life cycle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Regulation of CXCL-8 (Interleukin-8) Induction by Double-Stranded RNA Signaling Pathways during Hepatitis C Virus Infection

21 June 2018

1 reference

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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide

21 June 2018

1 reference

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Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma

21 June 2018

1 reference

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Herpes simplex virus and the chemokines that mediate the inflammation

21 June 2018

1 reference

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Hepatitis C virus glycoproteins mediate low pH-dependent membrane fusion with liposomes

21 June 2018

1 reference

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Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells

21 June 2018

1 reference

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Mechanisms of disease: Inflammation and the origins of cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Silymarin treatment of viral hepatitis: a systematic review

21 June 2018

1 reference

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Cytokines and respiratory syncytial virus infection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1

21 June 2018

1 reference

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Chemokine regulation of inflammation during acute viral infection

21 June 2018

1 reference

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Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function

21 June 2018

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Medicinal herbs for hepatitis C virus infection: a Cochrane hepatobiliary systematic review of randomized trials

21 June 2018

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Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

21 June 2018

1 reference

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Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein

21 June 2018

1 reference

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Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

21 June 2018

1 reference

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Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B.

21 June 2018

1 reference

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Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase.

21 June 2018

1 reference

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Chemokines: immunology's high impact factors

21 June 2018

1 reference

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Oxidative stress in symptom-free HCV carriers: relation with ALT flare-up.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Efficient initiation of HCV RNA replication in cell culture

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

A multicenter, randomized trial of daily high-dose interferon-alfa 2b for the treatment of chronic hepatitis c: pretreatment stratification by viral burden and genotype

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Treatment with silybin-vitamin E-phospholipid complex in patients with hepatitis C infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Gram-Scale Purification of Flavonolignan Diastereoisomers from Silybum marianum (Milk Thistle) Extract in Support of Preclinical in vivo Studies for Prostate Cancer Chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Evidence for action of ribavirin through the hepatitis C virus RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Binding of the bioflavonoid robinetin with model membranes and hemoglobin: Inhibition of lipid peroxidation and protein glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Ground and excited state proton transfer and antioxidant activity of 7-hydroxyflavone in model membranes: absorption and fluorescence spectroscopic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Hepatitis C virus proteins: direct link to hepatic oxidative stress, steatosis, carcinogenesis and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016464

Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030583

Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21297992

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21297992

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0016464

1 reference

3 November 2017

0 references

1 reference

3 November 2017

PubMed publication ID

21297992

1 reference