(Q31012928)

English

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

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scholarly article

1 reference

Europe PubMed Central

8 November 2017

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (English)

1 reference

Europe PubMed Central

8 November 2017

1 reference

based on heuristic

inferred from title

Danyel G.J. Jennen

4

object named as

Danyel Jennen

1 reference

Europe PubMed Central

8 November 2017

3

object named as

Jos Kleinjans

1 reference

Europe PubMed Central

8 November 2017

author name string

Ainhoa Ruiz-Aracama

1

1 reference

Europe PubMed Central

8 November 2017

Ad Peijnenburg

2

1 reference

Europe PubMed Central

8 November 2017

Joost van Delft

5

1 reference

Europe PubMed Central

8 November 2017

Caroline Hellfrisch

6

1 reference

Europe PubMed Central

8 November 2017

Arjen Lommen

7

1 reference

Europe PubMed Central

8 November 2017

language of work or name

0 references

publication date

20 May 2011

1 reference

Europe PubMed Central

8 November 2017

1 reference

Europe PubMed Central

8 November 2017

12

1 reference

Europe PubMed Central

8 November 2017

251

1 reference

Europe PubMed Central

8 November 2017

copyright license

Creative Commons Attribution 2.0 Generic

20 May 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

https://scigraph.springernature.com/pub.10.1186/1471-2164-12-251

0 references

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification

1 reference

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28 July 2018

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells

1 reference

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28 July 2018

NMR metabolomics and drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

MetAlign: interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Interlaboratory and interplatform comparison of microarray gene expression analysis of HepG2 cells exposed to benzo(a)pyrene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Metabolomics-assisted breeding: a viable option for crop improvement?

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28 July 2018

Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Differential signatures of protein glycosylation and phosphorylation in human Chang liver cells induced by TCDD treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Metabolomics: a global biochemical approach to drug response and disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Understanding mouse models of disease through metabolomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: a microarray study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Comparison of supervised clustering methods to discriminate genotoxic from non-genotoxic carcinogens by gene expression profiling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Identification of novel TCDD-regulated genes by microarray analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

TCDD administration after the pro-adipogenic differentiation stimulus inhibits PPARgamma through a MEK-dependent process but less effectively suppresses adipogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

N-acetylaspartate in the vertebrate brain: metabolism and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Genomics: an in vitro toxicology point of view.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

The role of O-linked protein glycosylation in beta-cell dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

An EU perspective on the use of in vitro methods in regulatory pharmaceutical toxicology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Molecular biology of the Ah receptor and its role in carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Proton NMR chemical shifts and coupling constants for brain metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Chemical fingerprinting for the evaluation of unintended secondary metabolic changes in transgenic food crops

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Acylcarnitines in intermediary metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

The aryl hydrocarbon receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Polyamine metabolism and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Comparative ability of TCDD to induce lipid peroxidation in rats, guinea pigs, and Syrian golden hamsters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and fasting on body weight and lipid parameters in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid synthesis and lipogenic enzymes in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Regulation of cellular glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Glutathione: toxicological implications

1 reference

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28 July 2018

Propionyl-L-carnitine: biochemical significance and possible role in cardiac metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Physiological actions of taurine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

The Ah receptor and the mechanism of dioxin toxicity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141663

28 July 2018

Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes

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21 January 2018

A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine.

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21 January 2018

Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling.

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21 January 2018

The potential of embryonic stem cells combined with -omics technologies as model systems for toxicology

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21 January 2018

Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria

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21 January 2018

Dioxin increases reactive oxygen production in mouse liver mitochondria

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21 January 2018

The transcriptional signature of dioxin in human hepatoma HepG2 cells

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21 January 2018

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

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21 January 2018

Aryl hydrocarbon receptor-mediated induction of the cytosolic phospholipase A(2)alpha gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse hepatoma Hepa-1c1c7 cells

1 reference

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21 January 2018

Involvement of SREBPs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of lipid metabolism in male guinea pig.

1 reference

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21 January 2018

Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver.

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21 January 2018

Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with induced adipocyte differentiation in mouse embryonic fibroblasts (MEFs) involves tyrosine kinase c-Src

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21 January 2018

Characterization of the hyperlipidemia in guinea pigs induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin

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21 January 2018

Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD

1 reference

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21 January 2018

Cytotoxicity and mitochondrial dysfunction of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in isolated rat hepatocytes.

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21 January 2018

Inhibition of TCDD-induced lipid peroxidation, glutathione peroxidase activity and toxicity by BHA and glutathione.

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21 January 2018

Regulation of polyamine synthesis in human hepatocytes by hepatotrophic factor augmenter of liver regeneration

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21 January 2018

EU research activities in alternative testing strategies: current status and future perspectives

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21 January 2018

Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry

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21 January 2018

Diagnosing inborn errors of lipid metabolism with proton nuclear magnetic resonance spectroscopy

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An untargeted metabolomics approach to contaminant analysis: Pinpointing potential unknown compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid profiles in tissue of the Fischer rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of ornithine decarboxylase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on de novo fatty acid and cholesterol synthesis in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the role of lipid peroxidation in the acute toxicity of TCDD in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of hepatic acetyl-CoA carboxylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agmatine, the bacterial amine, is widely distributed in mammalian tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartate complexes with calcium and lanthanide ions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dioxin causes a sustained oxidative stress response in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/21599895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2164-12-251

1 reference

Europe PubMed Central

8 November 2017

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1471-2164-12-251

1 reference

Europe PubMed Central

8 November 2017

1 reference

Europe PubMed Central

8 November 2017

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