(Q31028021)

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An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints

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Europe PubMed Central

PubMed publication ID

28 June 2017

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints (English)

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Europe PubMed Central

PubMed publication ID

28 June 2017

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Edwin J Matthews

1

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Europe PubMed Central

PubMed publication ID

28 June 2017

Naomi L Kruhlak

2

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Europe PubMed Central

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28 June 2017

Michael C Cimino

3

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Europe PubMed Central

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28 June 2017

R Daniel Benz

4

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28 June 2017

Joseph F Contrera

5

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Europe PubMed Central

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28 June 2017

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publication date

28 December 2005

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28 June 2017

Regulatory Toxicology and Pharmacology

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28 June 2017

44

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Europe PubMed Central

PubMed publication ID

28 June 2017

2

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Europe PubMed Central

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28 June 2017

83-96

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Europe PubMed Central

PubMed publication ID

28 June 2017

Alternatives to the 2-species bioassay for the identification of potential human carcinogens

1 reference

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Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP.

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Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

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Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program

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Availability of the GENE-TOX database on the National Library of Medicine TOXNET system

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Carcinogenicity testing and the evaluation of regulatory requirements for pharmaceuticals

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Predicting the carcinogenic potential of pharmaceuticals in rodents using molecular structural similarity and E-state indices

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Describing the validity of carcinogen screening tests

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Considerations in the U.S. Environmental Protection Agency's testing approach for mutagenicity

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Predicting rodent carcinogenicity from mutagenic potency measured in the Ames Salmonella assay

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Use of dual control groups to estimate false positive rates in laboratory animal carcinogenicity studies

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Comparison of the standard and reduced pH Syrian hamster embryo (SHE) cell in vitro transformation assays in predicting the carcinogenic potential of chemicals

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7 January 2021

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity

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A review and analysis of the Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase assay to determine the mutagenicity of chemical agents. A report of phase III of the U.S. Environmental Protection Agency Gene-Tox Program

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7 January 2021

Transformation of BALB/c-3T3 cells: I. Investigation of experimental parameters that influence detection of spontaneous transformation

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Transformation of BALB/c-3T3 cells: II. Investigation of experimental parameters that influence detection of benzo[a]pyrene-induced transformation

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Transformation of BALB/c-3T3 cells: III. Development of a co-culture clonal survival assay for quantification of chemical cytotoxicity in high-density cell cultures

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A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software

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Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure

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Transformation of BALB/c-3T3 cells: V. Transformation responses of 168 chemicals compared with mutagenicity in Salmonella and carcinogenicity in rodent bioassays

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Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals

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The L5178Y/tk+/- mouse lymphoma specific gene and chromosomal mutation assay a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program

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Mouse lymphoma thymidine kinase gene mutation assay: follow-up meeting of the International Workshop on Genotoxicity Testing--Aberdeen, Scotland, 2003--Assay acceptance criteria, positive controls, and data evaluation

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Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard

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Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program

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Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

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Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program

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Sister-chromatid exchange: second report of the Gene-Tox program

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Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: premises, promises, and performance

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Mutagens that are not carcinogens: faulty theory or faulty tests?

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Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals

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10.1016/J.YRTPH.2005.11.003

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

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