(Q31034258)

28 June 2017

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title

Methods to assess drug permeability across the blood-brain barrier (English)

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28 June 2017

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Joseph A Nicolazzo

1

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28 June 2017

Susan A Charman

series ordinal

2

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28 June 2017

William N Charman

series ordinal

3

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28 June 2017

language of work or name

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1 March 2006

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Journal of Pharmacy and Pharmacology

28 June 2017

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28 June 2017

58

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28 June 2017

281-293

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28 June 2017

3

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Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism.

28 June 2017

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

New positron emission tomography tracer [(11)C]carvedilol reveals P-glycoprotein modulation kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

How to measure drug transport across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Animal models for studying transport across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Junctions between intimately apposed cell membranes in the vertebrate brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

In silico prediction of blood–brain barrier permeation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Separation methods that are capable of revealing blood-brain barrier permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Potential role of ABC transporters as a detoxification system at the blood-CSF barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

A new multidrug resistance protein at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

An improved low-permeability in vitro-model of the blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

In vitro models for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Blood-brain interfaces: relevance to cerebral drug metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

PET studies on the brain uptake and regional distribution of [11C]vinpocetine in human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Whole-body autoradiography and quantitative organ-level distribution study of deramciclane in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Is nose-to-brain transport of drugs in man a reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Preferred stereoselective transport of the D-isomer of cis-4-[18F]fluoro-proline at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Development of a computational approach to predict blood-brain barrier permeability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Characterization of phosphine complexes of technetium(III) as transport substrates of the multidrug resistance P-glycoprotein and functional markers of P-glycoprotein at the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry--background and current status in the drug discovery process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Transport mechanism for aluminum citrate at the blood-brain barrier: kinetic evidence implies involvement of system Xc- in immortalized rat brain endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

The blood-brain barrier to horseradish peroxidase at the onset of bicuculline-induced seizures in hypothalamus, pallidum, hippocampus, and other selected regions of the rabbit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Computational approaches to the prediction of the blood-brain distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Blood-brain barrier biology and methodology

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Crossing the blood-brain barrier: are we getting it right?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

IAM chromatography: an in vitro screen for predicting drug membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Preliminary characterization of glial-secreted factors responsible for the induction of high electrical resistances across endothelial monolayers in a blood-brain barrier model

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Fine structural localization of a blood-brain barrier to exogenous peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

An overview of in vitro techniques for blood-brain barrier studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Relationship between immobilised artificial membrane chromatographic retention and the brain penetration of structurally diverse drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

A review of blood-brain barrier transport techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

In situ brain perfusion technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Use of immobilized artificial membrane chromatography for drug transport applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Transport of prostaglandin E1 across the blood-brain barrier in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Flavonoid permeability across an in situ model of the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Drug transport studies using quantitative microdialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Brain/blood distribution described by a combination of partition coefficient and molecular mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

21 January 2018

The Blood-Brain Barrier

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Blood-brain barrier transport of 125I-labeled basic fibroblast growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Holy grails and in vitro blood–brain barrier models

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

Log(BB), PS products and in silico models of drug brain penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.3.0001

21 January 2018

Identifiers

DOI

10.1211/JPP.58.3.0001

1 reference

28 June 2017

1 reference