(Q31038919)

28 June 2017

title

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex (English)

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28 June 2017

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ChEBI release 2020-05-28

5

Phillip Crews

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28 June 2017

Maina Lepourcelet

1

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28 June 2017

Ying-Nan P Chen

2

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28 June 2017

Dennis S France

3

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28 June 2017

Huisheng Wang

4

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28 June 2017

Frank Petersen

6

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28 June 2017

Charles Bruseo

7

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28 June 2017

Alexander W Wood

8

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28 June 2017

Ramesh A Shivdasani

9

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28 June 2017

publication date

1 January 2004

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28 June 2017

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28 June 2017

volume

5

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28 June 2017

issue

1

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28 June 2017

page(s)

91-102

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Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon

28 June 2017

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Anti-proliferative activity of protein kinase C in apical compartments of human colonic crypts: evidence for a less activated protein kinase C in small adenomas

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

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Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

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7 January 2021

A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus

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Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation

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Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C.

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Small molecule modulation of Smoothened activity

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In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis

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Essential role for oncogenic Ras in tumour maintenance

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Cell cycle-specific association of E2F with the p130 E1A-binding protein

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Protein-protein interfaces: mimics and inhibitors

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Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

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7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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7 January 2021

Stability and movement of mRNAs and their encoded proteins in Xenopus oocytes

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7 January 2021

Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex

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7 January 2021

Hot spots in Tcf4 for the interaction with beta-catenin

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Reversible tumorigenesis by MYC in hematopoietic lineages

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

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7 January 2021

Crystal structure of a beta-catenin/Tcf complex

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7 January 2021

Tcf4 can specifically recognize beta-catenin using alternative conformations

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7 January 2021

Beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts

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7 January 2021

Identification of c-MYC as a target of the APC pathway

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7 January 2021

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin

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7 January 2021

Beta-catenin mutations in cell lines established from human colorectal cancers

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7 January 2021

Novel marine sponge alkaloids 3. β-carbolinium salts from Fascaplysinopsis reticulata

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7 January 2021

Lessons from hereditary colorectal cancer

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7 January 2021

Thermodynamics of the high-affinity interaction of TCF4 with beta-catenin

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7 January 2021

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

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7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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7 January 2021

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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7 January 2021

The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway

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7 January 2021

Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway

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7 January 2021

A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation

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7 January 2021

Oncology drug discovery applications using the FMAT 8100 HTS system

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7 January 2021

Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression

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7 January 2021

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

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7 January 2021

Focus on colon cancer

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7 January 2021

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

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7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

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7 January 2021

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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7 January 2021

The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli

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7 January 2021

Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

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7 January 2021

Identification of Tcf4 residues involved in high-affinity beta-catenin binding

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7 January 2021

Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin

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7 January 2021

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

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7 January 2021

Structure of a human Tcf4-beta-catenin complex

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7 January 2021

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

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7 January 2021

Stabilization of beta-catenin by genetic defects in melanoma cell lines

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7 January 2021

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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7 January 2021

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

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7 January 2021

Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates

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7 January 2021

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

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7 January 2021

SF2446, new benzo[a]naphthacene quinone antibiotics. I. Taxonomy and fermentation of the producing strain, isolation and characterization of antibiotics.

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7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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7 January 2021

Inhibition of protein-protein association by small molecules: approaches and progress

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7 January 2021

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

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7 January 2021

TCF transcription factors, mediators of Wnt-signaling in development and cancer

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7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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7 January 2021

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

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7 January 2021

10.1016/S1535-6108(03)00334-9

Identifiers

DOI

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28 June 2017

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