(Q31048075)

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Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

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scholarly article

1 reference

Europe PubMed Central

13 October 2017

1 reference

8 February 2021

Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors (English)

1 reference

Europe PubMed Central

13 October 2017

mitochondrial DNA

1 reference

20 September 2020

1 reference

6 November 2020

1 reference

8 February 2021

genetic selection

1 reference

David C. Samuels

4

1 reference

Europe PubMed Central

13 October 2017

author name string

Valdemar Máximo

3

1 reference

Europe PubMed Central

13 October 2017

language of work or name

0 references

publication date

2 February 2012

9 references

Europe PubMed Central

13 October 2017

3 April 2019

20 June 2019

30 June 2019

2 August 2019

14 September 2019

20 September 2020

6 November 2020

8 February 2021

9 references

Europe PubMed Central

13 October 2017

3 April 2019

20 June 2019

30 June 2019

2 August 2019

14 September 2019

20 September 2020

6 November 2020

8 February 2021

12

1 reference

Europe PubMed Central

13 October 2017

53

1 reference

Europe PubMed Central

13 October 2017

copyright license

Creative Commons Attribution 2.0 Generic

8 references

Europe PubMed Central

3 April 2019

Europe PubMed Central

20 June 2019

Europe PubMed Central

30 June 2019

Europe PubMed Central

2 August 2019

Europe PubMed Central

14 September 2019

Europe PubMed Central

20 September 2020

Europe PubMed Central

6 November 2020

Europe PubMed Central

8 February 2021

copyright status

0 references

on focus list of Wikimedia project

0 references

https://scigraph.springernature.com/pub.10.1186/1471-2407-12-53

0 references

Comparing phylogeny and the predicted pathogenicity of protein variations reveals equal purifying selection across the global human mtDNA diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Potential pitfalls in MitoChip detected tumor-specific somatic mutations: a call for caution when interpreting patient data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Learning from oncocytic tumors: Why choose inefficient mitochondria?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Mitochondrial mutations in hepatocellular carcinomas and fibrolamellar carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Molecular features of thyroid oncocytic tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Somatic mutations of mitochondrial genome in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Automated inference of molecular mechanisms of disease from amino acid substitutions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Functional annotations improve the predictive score of human disease-related mutations in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

The diversity present in 5140 human mitochondrial genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Contamination and sample mix-up can best explain some patterns of mtDNA instabilities in buccal cells and oral squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

MtDNA mutation pattern in tumors and human evolution are shaped by similar selective constraints.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Hypoxia and adaptive landscapes in the evolution of carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Mitochondrial mutations in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

A critical reassessment of the role of mitochondria in tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

The role of selection in the evolution of human mitochondrial genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Possibility of selection against mtDNA mutations in tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Hürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

mtDNA mutations increase tumorigenicity in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

High frequency of somatic mitochondrial DNA mutations in human thyroid carcinomas and complex I respiratory defect in thyroid cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Mitochondrial DNA mutations in breast cancer tissue and in matched nipple aspirate fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Effects of purifying and adaptive selection on regional variation in human mtDNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Natural selection shaped regional mtDNA variation in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Facile detection of mitochondrial DNA mutations in tumors and bodily fluids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

Somatic mutations of the mitochondrial genome in human colorectal tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

21 June 2018

The power to detect disease associations with mitochondrial DNA haplogroups

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

The pattern of natural selection in somatic cancer mutations of human mtDNA.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Accumulation of mutations over the entire mitochondrial genome of breast cancer cells obtained by tissue microdissection.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Somatic mitochondrial mutations in pilocytic astrocytoma.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Novel heteroplasmic frameshift and missense somatic mitochondrial DNA mutations in oral cancer of betel quid chewers

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

mtDNA tree Build 17 (18 Feb 2016)

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

HaploGrep: a fast and reliable algorithm for automatic classification of mitochondrial DNA haplogroups.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Performance of mutation pathogenicity prediction methods on missense variants

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https://api.crossref.org/works/10.1186%2F1471-2407-12-53

21 January 2018

Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342922

25 November 2018

Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mitochondrial DNA mutations in adult-onset leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between mitochondrial DNA mutations and clinical characteristics in human lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mitochondrial DNA mutations in human chromophobe renal cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects of the respiratory chain in oxyphil and chief cells of the normal parathyroid and in hyperfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rate variation between mitochondrial domains and adaptive evolution in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluating mitochondrial DNA in patients with breast cancer and benign breast disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2407-12-53

1 reference

Europe PubMed Central

13 October 2017

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1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

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