(Q31074393)

12 August 2017

H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling (English)

1 reference

12 August 2017

endoplasmic reticulum

0 references

John F Woolley

1

0 references

author name string

Ruth Naughton

2

1 reference

12 August 2017

Joanna Stanicka

3

1 reference

12 August 2017

David R Gough

4

1 reference

12 August 2017

Lavinia Bhatt

5

1 reference

12 August 2017

Bryan C Dickinson

6

1 reference

12 August 2017

Christopher J Chang

7

1 reference

12 August 2017

Thomas G Cotter

8

1 reference

12 August 2017

language of work or name

English

0 references

publication date

13 July 2012

1 reference

12 August 2017

1 reference

12 August 2017

7

1 reference

12 August 2017

7

1 reference

12 August 2017

e34050

1 reference

Creative Commons Attribution 4.0 International

12 August 2017

start time

13 July 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein.

21 June 2018

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Chemistry and biology of reactive oxygen species in signaling or stress responses

21 June 2018

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Do reactive oxygen species play a role in myeloid leukemias?

21 June 2018

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NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox

21 June 2018

1 reference

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NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases

21 June 2018

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FLT3 as a therapeutic target in AML: still challenging after all these years

21 June 2018

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A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells

21 June 2018

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Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death

21 June 2018

1 reference

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Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome.

21 June 2018

1 reference

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Hydrogen peroxide as a cell-survival signaling molecule.

21 June 2018

1 reference

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NOX enzymes in the central nervous system: from signaling to disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes

21 June 2018

1 reference

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Compartmentalization of redox signaling through NADPH oxidase-derived ROS.

21 June 2018

1 reference

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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

21 June 2018

1 reference

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Targeting FLT3 for the treatment of leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Deregulation of signaling pathways in acute myeloid leukemia

21 June 2018

1 reference

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Biological roles for the NOX family NADPH oxidases

21 June 2018

1 reference

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Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML.

21 June 2018

1 reference

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Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.

21 June 2018

1 reference

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Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

NOX2 and NOX4 mediate proliferative response in endothelial cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Cell signaling. H2O2, a necessary evil for cell signaling

21 June 2018

1 reference

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Signal transduction of oncogenic Flt3.

21 June 2018

1 reference

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Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

The serine/threonine kinase Pim-1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

cAMP-induced degradation of cyclin D3 through association with GSK-3beta

21 June 2018

1 reference

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Reactive oxygen species in oncogenic transformation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

The role of FLT3 in haematopoietic malignancies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

The roles of FLT3 in hematopoiesis and leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Oncogenic kinase signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Hematopoietic growth factors signal through the formation of reactive oxygen species

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Persistent oxidative stress in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Production of large amounts of hydrogen peroxide by human tumor cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034050

Expression and localization of NOX2 and NOX4 in primary human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034050

NAD(P)H oxidases regulate HIF-2alpha protein expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034050

Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034050

Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034050

A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396659

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22807997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22807997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22807997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0034050

1 reference

12 August 2017

0 references

1 reference

12 August 2017

PubMed publication ID

22807997

1 reference