(Q31094570)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

0 references

0 references

1 reference

1 reference

2

1 reference

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13 February 2020

Joshua Ko

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Pui-Ching Law

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Lok-Yi Chan

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

publication date

19 September 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

BMC Complementary and Alternative Medicine

13 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

12

1 reference

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13 February 2020

page(s)

160

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 2.0 Generic

13 February 2020

copyright license

start time

19 September 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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21 June 2018

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Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats

21 June 2018

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Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2

21 June 2018

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A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene.

21 June 2018

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Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB.

21 June 2018

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21 June 2018

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Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

21 June 2018

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21 June 2018

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Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases

21 June 2018

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Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways

21 June 2018

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NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms

21 June 2018

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Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

21 June 2018

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21 June 2018

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Targeting HIF-1 for cancer therapy

21 June 2018

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21 June 2018

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Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the c

21 June 2018

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 June 2018

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Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

21 June 2018

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 June 2018

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The contributions of cyclooxygenase-2 to tumor angiogenesis

21 June 2018

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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

21 June 2018

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Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line

21 June 2018

1 reference

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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

21 June 2018

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Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

21 June 2018

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

21 June 2018

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Cyclooxygenase regulates angiogenesis induced by colon cancer cells

21 June 2018

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 June 2018

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Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

21 June 2018

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 June 2018

1 reference

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21 June 2018

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

21 June 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 June 2018

1 reference

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Akt mediates an angiogenic switch in transformed keratinocytes

21 June 2018

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Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha

21 January 2018

1 reference

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Potent inhibition of in vivo angiogenesis and tumor growth by a novel cyclooxygenase-2 inhibitor, enoic acanthoic acid.

21 January 2018

1 reference

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Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves

21 January 2018

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Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation.

21 January 2018

1 reference

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Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1

25 November 2018

1 reference

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The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

25 November 2018

1 reference

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Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors

25 November 2018

1 reference

12 December 2020

Differential Role of bFGF and VEGF for Vasculogenesis

1 reference

12 December 2020

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

1 reference

12 December 2020

Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells

1 reference

12 December 2020

Direct Transcriptional Up-regulation of Cyclooxygenase-2 by Hypoxia-Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF-1 Transcriptional Activity during Hypoxia

1 reference

12 December 2020

Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft

1 reference

12 December 2020

Systemic treatment of colorectal cancer

1 reference

12 December 2020

mTOR Signaling is Involved in Indomethacin and Nimesulide Suppression of Colorectal Cancer Cell Growth via a COX-2 Independent Pathway

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12 December 2020

Identifiers

DOI

10.1186/1472-6882-12-160

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

22992293

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992293%20AND%20SRC:MED&resulttype=core&format=json