(Q31567026)

2 July 2017

title

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription (English)

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2 July 2017

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J P Blaydes

1

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2 July 2017

M G Luciani

2

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2 July 2017

S Pospisilova

3

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2 July 2017

H M Ball

4

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2 July 2017

B Vojtesek

5

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2 July 2017

T R Hupp

6

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2 July 2017

language of work or name

English

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publication date

14 November 2000

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Journal of Biological Chemistry

2 July 2017

published in

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2 July 2017

volume

276

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2 July 2017

issue

7

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2 July 2017

page(s)

4699-4708

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Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

2 July 2017

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis.

21 January 2018

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Definition of a consensus binding site for p53

21 January 2018

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Sequence-specific transcriptional activation is essential for growth suppression by p53.

21 January 2018

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Recruitment of p300/CBP in p53-dependent signal pathways

21 January 2018

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Functional interplay between p53 and E2F through co-activator p300.

21 January 2018

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

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Refined solution structure of the oligomerization domain of the tumour suppressor p53

21 January 2018

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Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

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DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M003485200

SUMO-1 modification activates the transcriptional response of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M003485200

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M003485200

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M003485200

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

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Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

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The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

21 January 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

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Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

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The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.

21 January 2018

1 reference

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Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53.

21 January 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

21 January 2018

1 reference

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Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

21 January 2018

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Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments

21 January 2018

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Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M003485200

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Phosphorylation studies on rat p53 using the baculovirus expression system. Manipulation of the phosphorylation state with okadaic acid and influence on DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Precise characterisation of monoclonal antibodies to the C-terminal region of p53 protein using the PEPSCAN ELISA technique and a new non-radioactive gel shift assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Allosteric activation of latent p53 tetramers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

PAK1, a gene that can regulate p53 activity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Mutation of phosphoserine 389 affects p53 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

In vivo regulation of cyclin A/Cdc2 and cyclin B/Cdc2 through meiotic and early cleavage cycles in starfish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Kinase-independent activity of Cdc2/cyclin A prevents the S phase in the Drosophila cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Strategies for manipulating the p53 pathway in the treatment of human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Phosphorylation of p53 serine 15 increases interaction with CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

p53-Dependent growth arrest and altered p53-immunoreactivity following metabolic labelling with 32P ortho-phosphate in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

RB regulates the stability and the apoptotic function of p53 via MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

Enhanced binding activity observed between anti-carcinoembryonic monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003485200

21 January 2018

Identifiers

DOI

10.1074/JBC.M003485200

1 reference

2 July 2017

1 reference